Sporotrichosis

Lymphocutaneous/cutaneous sporotrichosis: follow-up is clinical and antifungal therapy should be continued for 2 to 4 weeks after resolution of all skin lesions. If the patient fails initial itraconazole treatment and is retreated with itraconazole at higher doses, serum drug levels should be monitored to ensure adequate absorption (target level: >1 microgram/mL). Patients receiving terbinafine should have monthly liver function testing.

Extracutaneous sporotrichosis: patients treated with amphotericin B should have careful monitoring of their renal function. In patients treated with itraconazole, serum drug levels should be monitored to ensure adequate absorption (target level: >1 microgram/mL).