Evidence
This page contains a snapshot of featured content which highlights evidence addressing key clinical questions including areas of uncertainty. Please see the main topic reference list for details of all sources underpinning this topic.
BMJ Best Practice evidence tables
Evidence tables provide easily navigated layers of evidence in the context of specific clinical questions, using GRADE and a BMJ Best Practice Effectiveness rating. Follow the links at the bottom of the table, which go to the related evidence score in the main topic text, providing additional context for the clinical question. Find out more about our evidence tables.
This table is a summary of the analysis reported in a Cochrane Clinical Answer that focuses on the above important clinical question.
Confidence in the evidence is moderate or low to moderate where GRADE has been performed and the intervention may be more effective/beneficial than the comparison for key outcomes.
Population: Children and adults (5 to 87 years) with either suspected or confirmed Strongyloides stercoralis infection
Intervention: Ivermectin
Comparison: Albendazole
| Outcome | Effectiveness (BMJ rating)? | Confidence in evidence (GRADE)? |
|---|---|---|
Parasitological cure (follow‐up: 5 weeks) | Favors intervention | Moderate |
Adverse events (follow‐up: 5 weeks) | No statistically significant difference | Low |
Note The Cochrane review which underpins this Cochrane Clinical Answer (CCA) noted that current evidence is insufficient regarding treatment effectiveness in very young or very old patients, or in people with some underlying immunosuppresive disorders. The CCA also includes results for ivermectin versus thiabendazole with low-quality evidence showing similar parasitological cure rates in both treatment groups, while moderate-quality evidence found that adverse events occurred more frequently in the thiabendazole group.
This evidence table is related to the following section/s:
Cochrane Clinical Answers
Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.
- How does ivermectin compare with albendazole or thiabendazole for the treatment of Strongyloides stercoralis infection?
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