Paroxysmal nocturnal hemoglobinuria

Recommendations of the International PNH Interest Group[24]Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005 Dec 1;106(12):3699-709. http://www.bloodjournal.org/content/106/12/3699.full http://www.ncbi.nlm.nih.gov/pubmed/16051736?tool=bestpractice.com

The diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) requires evidence of red blood cells and/or granulocytes lacking (completely or partially) the glycosylphosphatidylinositol anchor or proteins attached by that anchor. Subgroups (classic PNH, PNH in the setting of another specified bone marrow disorder, and subclinical PNH) are determined by the complete blood count, serum lactate dehydrogenase, bilirubin, and haptoglobin concentration, as well as the bone marrow aspirate, biopsy, and cytogenetics.