In general, the outlook for most patients with brachial plexus birth injury (BPBI) is good.[162]Bae DS, Zurakowski D, Avallone N, et al. Sports participation in selected children with brachial plexus birth palsy. J Pediatr Orthop. 2009 Jul-Aug;29(5):496-503.
http://www.ncbi.nlm.nih.gov/pubmed/19568024?tool=bestpractice.com
Many series have reported full recovery in more than 70% to 80% of children with BPBI, with absent to minimal long-term sequelae.[49]Zafeiriou DI, Psychogiou K. Obstetrical brachial plexus palsy. Pediatr Neurol. 2008 Apr;38(4):235-42.
http://www.ncbi.nlm.nih.gov/pubmed/18358400?tool=bestpractice.com
[108]Basit H, Ali CDM, Madhani NB. Erb palsy. 2022 Feb 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Feb 27.
https://www.ncbi.nlm.nih.gov/books/NBK513260
http://www.ncbi.nlm.nih.gov/pubmed/30020632?tool=bestpractice.com
[163]Bénié CA, Akobé JRA, Lohourou FG, et al. Obstetrical brachial plexus palsy (PBOPP): epidemiological, therapeutic and evolutionary features of patients at the Bouaké University Hospital, Ivory Coast [in French]. Pan Afr Med J. 2021;38:309.
http://www.ncbi.nlm.nih.gov/pubmed/34178227?tool=bestpractice.com
The extent of nerve injury affects the degree of spontaneous recovery, and declines with increasing Narakas group as follows:[14]Al-Qattan MM, El-Sayed AA, Al-Zahrani AY, et al. Narakas classification of obstetric brachial plexus palsy revisited. J Hand Surg Eur Vol. 2009 Dec;34(6):788-91.
http://www.ncbi.nlm.nih.gov/pubmed/19786407?tool=bestpractice.com
[96]Pondaag W, Malessy MJA. Evidence that nerve surgery improves functional outcome for obstetric brachial plexus injury. J Hand Surg Eur Vol. 2021 Mar;46(3):229-36.
https://www.doi.org/10.1177/1753193420934676
http://www.ncbi.nlm.nih.gov/pubmed/32588706?tool=bestpractice.com
Group 1: rate of spontaneous recovery >80%
Group 2: rate of spontaneous recovery around 60%
Group 3: rate of spontaneous recovery <50%
Group 4: rate spontaneous recovery around 0%.
Children without full recovery by the age of 3 months are likely to have some residual impairment.[6]Smith NC, Rowan P, Benson LJ, et al. Neonatal brachial plexus palsy: outcome of absent biceps function at three months of age. J Bone Joint Surg Am. 2004 Oct;86-A(10):2163-70.
http://www.ncbi.nlm.nih.gov/pubmed/15466724?tool=bestpractice.com
[64]Waters PM. Comparison of the natural history, the outcome of microsurgical repair, and the outcome of operative reconstruction in brachial plexus birth palsy. J Bone Joint Surg Am. 1999 May;81(5):649-59.
http://www.ncbi.nlm.nih.gov/pubmed/10360693?tool=bestpractice.com
[91]Hems TEJ, Savaridas T, Sherlock DA. The natural history of recovery of elbow flexion after obstetric brachial plexus injury managed without nerve repair. J Hand Surg Eur Vol. 2017 Sep;42(7):706-9.
http://www.ncbi.nlm.nih.gov/pubmed/28627963?tool=bestpractice.com
[110]Annika J, Paul U, Anna-Lena L. Obstetric brachial plexus palsy - A prospective, population-based study of incidence, recovery and long-term residual impairment at 10 to 12 years of age. Eur J Paediatr Neurol. 2019 Jan;23(1):87-93.
https://www.doi.org/10.1016/j.ejpn.2018.06.006
http://www.ncbi.nlm.nih.gov/pubmed/30458977?tool=bestpractice.com
Long term deficits most commonly include restriction of shoulder movement, flexion contracture of the elbow, and reduction in forearm rotation. It is rare for active elbow flexion to not recover well.[91]Hems TEJ, Savaridas T, Sherlock DA. The natural history of recovery of elbow flexion after obstetric brachial plexus injury managed without nerve repair. J Hand Surg Eur Vol. 2017 Sep;42(7):706-9.
http://www.ncbi.nlm.nih.gov/pubmed/28627963?tool=bestpractice.com
[96]Pondaag W, Malessy MJA. Evidence that nerve surgery improves functional outcome for obstetric brachial plexus injury. J Hand Surg Eur Vol. 2021 Mar;46(3):229-36.
https://www.doi.org/10.1177/1753193420934676
http://www.ncbi.nlm.nih.gov/pubmed/32588706?tool=bestpractice.com
Hand function in children with severe global palsies improves after surgery in 48% to 93%, depending on definition.[96]Pondaag W, Malessy MJA. Evidence that nerve surgery improves functional outcome for obstetric brachial plexus injury. J Hand Surg Eur Vol. 2021 Mar;46(3):229-36.
https://www.doi.org/10.1177/1753193420934676
http://www.ncbi.nlm.nih.gov/pubmed/32588706?tool=bestpractice.com
In many children, the affected limb becomes nondominant, but activities that require bimanual function can be impacted.[96]Pondaag W, Malessy MJA. Evidence that nerve surgery improves functional outcome for obstetric brachial plexus injury. J Hand Surg Eur Vol. 2021 Mar;46(3):229-36.
https://www.doi.org/10.1177/1753193420934676
http://www.ncbi.nlm.nih.gov/pubmed/32588706?tool=bestpractice.com
[164]Medeiros DL, Agostinho NB, Mochizuki L, et al. Quality of life and upper limb function of children with neonatal brachial plexus palsy. [in Portuguese]. Rev Paul Pediatr. 2020;38:e2018304.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063594
http://www.ncbi.nlm.nih.gov/pubmed/32159646?tool=bestpractice.com
Some adults with BPBI go on to glenohumeral joint arthroplasty or arthrodesis.[165]Werthel JD, Schoch B, Frankle M, et al. Shoulder arthroplasty for sequelae of obstetrical brachial plexus injury. J Hand Surg Am. 2018 Sep;43(9):871.e1-871.e7.
https://www.doi.org/10.1016/j.jhsa.2018.02.006
http://www.ncbi.nlm.nih.gov/pubmed/29605518?tool=bestpractice.com
[166]Belkheyar Z, Belkacem Djeffel A, Cambon-Binder A. Glenohumeral fusion in adults with sequelae of obstetrical brachial plexus injury: a report of eight cases. J Hand Surg Eur Vol. 2019 Mar;44(3):248-55.
http://www.ncbi.nlm.nih.gov/pubmed/30466377?tool=bestpractice.com
The long-term ability to perform activities of daily living and general function is good for most patients despite these limitations.[110]Annika J, Paul U, Anna-Lena L. Obstetric brachial plexus palsy - A prospective, population-based study of incidence, recovery and long-term residual impairment at 10 to 12 years of age. Eur J Paediatr Neurol. 2019 Jan;23(1):87-93.
https://www.doi.org/10.1016/j.ejpn.2018.06.006
http://www.ncbi.nlm.nih.gov/pubmed/30458977?tool=bestpractice.com
[167]Hulleberg G, Elvrum AK, Brandal M, et al. Outcome in adolescence of brachial plexus birth palsy. 69 individuals re-examined after 10–20 years. Acta Orthop. 2014 Dec;85(6):633-40
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259022
http://www.ncbi.nlm.nih.gov/pubmed/25238434?tool=bestpractice.com
[168]Butler L, Mills J, Richard HM, et al. Long-term follow-up of neonatal brachial plexopathy: psychological and physical function in adolescents and young adults. J Pediatr Orthop. 2017 Sep;37(6):e364-8.
http://www.ncbi.nlm.nih.gov/pubmed/28719549?tool=bestpractice.com
[169]Ploetze K, Goldfarb C, Roberts S, et al. Radiographic and clinical outcomes of the shoulder in long-term follow-up of brachial plexus birth injury. J Hand Surg Am. 2020 Dec;45(12):1115-22.
http://www.ncbi.nlm.nih.gov/pubmed/33289634?tool=bestpractice.com
Children who do not experience full recovery will often have impairments of function requiring modification of activities, ongoing therapy, or surgical intervention; this may impact quality of life.[170]Yau CWH, Pizzo E, Prajapati C, et al. Obstetric brachial plexus injuries (OBPIs): health-related quality of life in affected adults and parents. Health Qual Life Outcomes. 2018 Nov 15;16(1):212.
https://www.doi.org/10.1186/s12955-018-1039-z
http://www.ncbi.nlm.nih.gov/pubmed/30442125?tool=bestpractice.com
Some studies have found reduced mental health in children with BPBI but self-concept and social functioning were good in one study.[164]Medeiros DL, Agostinho NB, Mochizuki L, et al. Quality of life and upper limb function of children with neonatal brachial plexus palsy. [in Portuguese]. Rev Paul Pediatr. 2020;38:e2018304.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063594
http://www.ncbi.nlm.nih.gov/pubmed/32159646?tool=bestpractice.com
[171]Mentrikoski JM, Duncan CL, Melanson A, et al. Factors related to the psychosocial functioning of youth with neonatal brachial plexus injuries. J Pediatr Psychol. 2015 Apr;40(3):285-96.
https://academic.oup.com/jpepsy/article/40/3/285/2580206?login=false
http://www.ncbi.nlm.nih.gov/pubmed/25294841?tool=bestpractice.com
Additionally, ongoing medical malpractice litigation has been associated with worse parent reported function and pain.[172]Eismann EA, Bauer A, Kozin SH, et al. The relationship between medical malpractice litigation and parent reports of patient function following neonatal brachial plexus palsy. J Bone Joint Surg Am. 2014 Mar 5;96(5):373-9.
http://www.ncbi.nlm.nih.gov/pubmed/24599198?tool=bestpractice.com