Patient outcomes depend upon multiple factors, including unilateral versus bilateral cryptorchidism, location of cryptorchid testis, and age at surgical correction. Successful surgical correction, defined as scrotal position without atrophy, has been reported as 92% to 95% for testes located beyond the external inguinal ring; failure rates increase for testes in higher locations.[97]Docimo SG. The results of surgical therapy for cryptorchidism: a literature review and analysis. J Urol. 1995 Sep;154(3):1148-52.
http://www.ncbi.nlm.nih.gov/pubmed/7637073?tool=bestpractice.com
[98]Taran I, Elder JS. Results of orchiopexy for the undescended testis. World J Urol. 2006 Aug;24(3):231-9.
http://www.ncbi.nlm.nih.gov/pubmed/16676187?tool=bestpractice.com
While the rates of testicular cancer may be somewhat higher in patients with cryptorchidism who undergo early orchiopexy compared with the general population, rates of malignancy are increased nearly 6 times in patients who undergo late surgical correction or do not undergo correction of cryptorchidism compared with patients who undergo early orchiopexy.[75]Pettersson A, Richiardi L, Nordenskjold A, et al. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007 May 3;356(18):1835-41.
https://www.nejm.org/doi/full/10.1056/NEJMoa067588
http://www.ncbi.nlm.nih.gov/pubmed/17476009?tool=bestpractice.com
[112]Walsh TJ, Dall'Era MA, Croughan MS, et al. Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer. J Urol. 2007 Oct;178(4 Pt 1):1440-6.
http://www.ncbi.nlm.nih.gov/pubmed/17706709?tool=bestpractice.com
The chance of later neoplasia in a boy born with unilateral undescended testicle is approximately 1 in 120, and with bilateral undescended testicles the chance is approximately 1 in 44. The higher the testis is in the abdomen, the higher the risk appears to be.[75]Pettersson A, Richiardi L, Nordenskjold A, et al. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007 May 3;356(18):1835-41.
https://www.nejm.org/doi/full/10.1056/NEJMoa067588
http://www.ncbi.nlm.nih.gov/pubmed/17476009?tool=bestpractice.com
[112]Walsh TJ, Dall'Era MA, Croughan MS, et al. Prepubertal orchiopexy for cryptorchidism may be associated with lower risk of testicular cancer. J Urol. 2007 Oct;178(4 Pt 1):1440-6.
http://www.ncbi.nlm.nih.gov/pubmed/17706709?tool=bestpractice.com
Increasingly, cryptorchid patients who are infertile are using assisted reproduction and testis sperm retrieval. Often sperm can be retrieved in adult men with azoospermia with repaired uni- or bilaterally undescended testes.[113]Raman JD, Schlegel PN. Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism. J Urol. 2003 Oct;170(4 Pt 1):1287-90.
http://www.ncbi.nlm.nih.gov/pubmed/14501743?tool=bestpractice.com