Cellulitis is a common condition. One population-based study in Minnesota limited to cellulitis involving a lower extremity found an incidence of 199 episodes per 100,000 person-years.[2]Mcnamara DR, Tleyjeh IM, Berbari EF, et al. Incidence of lower-extremity cellulitis: a population-based study in Olmsted County, Minnesota. Mayo Clin Proc. 2007 Jul;82(7):817-21.
http://www.ncbi.nlm.nih.gov/pubmed/17605961?tool=bestpractice.com
In an Australian study, the overall annual incidence of primary episodes of lower limb cellulitis was 205 per 100,000 population.[3]Cannon J, Rajakaruna G, Dyer J, et al. Severe lower limb cellulitis: defining the epidemiology and risk factors for primary episodes in a population-based case-control study. Clin Microbiol Infect. 2018 Oct;24(10):1089-94.
https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(18)30142-3/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/29427797?tool=bestpractice.com
Annual incidence of cellulitis in the Netherlands is estimated to be 22 per 1000 inhabitants.[4]Cranendonk DR, Lavrijsen APM, Prins JM, et al. Cellulitis: current insights into pathophysiology and clinical management. Neth J Med. 2017 Nov;75(9):366-78.
http://www.njmonline.nl/article.php?a=1907&d=1260&i=210
http://www.ncbi.nlm.nih.gov/pubmed/29219814?tool=bestpractice.com
Sex did not affect the rate, but increasing age is associated with a higher incidence.[2]Mcnamara DR, Tleyjeh IM, Berbari EF, et al. Incidence of lower-extremity cellulitis: a population-based study in Olmsted County, Minnesota. Mayo Clin Proc. 2007 Jul;82(7):817-21.
http://www.ncbi.nlm.nih.gov/pubmed/17605961?tool=bestpractice.com
In one study over a 12-month period from 2014 to 2015, the cellulitis hospitalization rate was 1100 per 100,000 in people ages 80 years and over, as opposed to 237 episodes per 100,000 in the general population.[5]Kumar M, Jong Ngian VJ, Yeong C, et al. Cellulitis in older people over 75 years - are there differences? Ann Med Surg (Lond). 2020 Jan;49:37-40.
https://www.sciencedirect.com/science/article/pii/S2049080119301803?via%3Dihub
http://www.ncbi.nlm.nih.gov/pubmed/31867103?tool=bestpractice.com
Admissions for cellulitis consistently peak in summer months, with this seasonality observed in several countries.[6]Peterson RA, Polgreen LA, Cavanaugh JE, et al. Increasing incidence, cost, and seasonality in patients hospitalized for cellulitis. Open Forum Infect Dis. 2017 Winter;4(1):ofx008.
https://academic.oup.com/ofid/article/4/1/ofx008/2978056
http://www.ncbi.nlm.nih.gov/pubmed/28480281?tool=bestpractice.com
[7]Hsu RJ, Chou CC, Liu JM, et al. The association of cellulitis incidence and meteorological factors in Taiwan. Epidemiol Infect. 2019 Jan;147:e138.
https://www.cambridge.org/core/journals/epidemiology-and-infection/article/association-of-cellulitis-incidence-and-meteorological-factors-in-taiwan/1F6217953A0A5052F8AC4FFA1D9C4782
http://www.ncbi.nlm.nih.gov/pubmed/30869041?tool=bestpractice.com
[8]Manning L, Cannon J, Dyer J, et al. Seasonal and regional patterns of lower leg cellulitis in Western Australia. Intern Med J. 2019 Feb;49(2):212-6.
https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14034
http://www.ncbi.nlm.nih.gov/pubmed/29984905?tool=bestpractice.com
The past two decades have seen an increase in visits for skin infection with community-associated MRSA; however, further analysis concluded this was mostly due to abscesses rather than cellulitis.[9]Kaye KS, Petty LA, Shorr AF, et al. Current epidemiology, etiology, and burden of acute skin infections in the United States. Clin Infect Dis. 2019 Apr 8;68(suppl 3):S193-9.
https://academic.oup.com/cid/article/68/Supplement_3/S193/5428806
http://www.ncbi.nlm.nih.gov/pubmed/30957165?tool=bestpractice.com
[10]Pallin DJ, Egan DJ, Pelletier AJ, et al. Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus. Ann Emerg Med. 2008 Mar;51(3):291-8.
http://www.ncbi.nlm.nih.gov/pubmed/18222564?tool=bestpractice.com
[11]Qualls ML, Mooney MM, Camargo CA Jr, et al. Emergency department visit rates for abscess versus other skin infections during the emergence of community-associated methicillin-resistant Staphylococcus aureus, 1997-2007. Clin Infect Dis. 2012 Jul;55(1):103-5.
http://cid.oxfordjournals.org/content/55/1/103.long
http://www.ncbi.nlm.nih.gov/pubmed/22460965?tool=bestpractice.com