Epidemiology

PDB is the second most common chronic bone-remodeling disorder after osteoporosis.[3] The majority of cases are sporadic, but between 5% and 40% of patients report a first-degree relative with PDB.[4]

Prevalence is approximately 1% in the general US population, rising to 2.32% in people ages 65 to 74 years.[5] There is a slight increased distribution in the northeast region compared with other regions in the US. The mean age of onset is 55 years, with equal distribution among men and women (although there is a slight male predominance in the 45- to 74-year age group).[5] An overall prevalence of 2% has been reported in the UK.[6] Prevalence in Europe is 0.3%.[7] A decrease in prevalence since the 1990s has been reported in most countries.[8]

PDB may be either monostotic (25%), involving most frequently the femur, or polyostotic (75%), involving most frequently the femur, pelvis, skull, tibia, or vertebrae.[1][2]

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