Screening
The majority of pituitary tumors are sporadic. However, about 5% present in a familial setting. Consider screening young patients (<30 years at diagnosis) presenting with large prolactinomas for aryl hydrocarbon receptor-interacting protein (AIP) gene mutations and multiple endocrine neoplasia syndrome type 1.[6][7] In studies of patients with familial isolated pituitary adenoma, prolactinomas associated with AIP gene mutations were large, occurred at a young age (<30 years), were invasive, had suprasellar extension, and were resistant to dopamine agonist treatment.[4][5]
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