Giardia is one of the most commonly diagnosed intestinal protozoa.[11]Pires SM, Fischer-Walker CL, Lanata CF, et al. Aetiology-specific estimates of the global and regional incidence and mortality of diarrhoeal diseases commonly transmitted through food. PLoS One. 2015 Dec 3;10(12):e0142927.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142927
http://www.ncbi.nlm.nih.gov/pubmed/26632843?tool=bestpractice.com
[12]Coelho CH, Durigan M, Leal DAG, et al. Giardiasis as a neglected disease in Brazil: systematic review of 20 years of publications. PLoS Negl Trop Dis. 2017 Oct 24;11(10):e0006005.
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006005
http://www.ncbi.nlm.nih.gov/pubmed/29065126?tool=bestpractice.com
It is commonly identified in tropical and temperate regions of the world and is more prevalent in rural areas, and in low- and middle- income countries where exposure is nearly universal.
Nearly 15,000 cases of Giardiawere reported in the US in 2019.[13]Centers for Disease Control and Prevention. Waterborne disease and outbreak surveillance reporting: giardiasis NNDSS summary report for 2019. May 2024 [internet publication].
https://www.cdc.gov/healthy-water-data/documentation/giardiasis-nndss-summary-report-for-2019.html
Most cases are sporadic (non-outbreak). Outbreaks are increasingly less common in the US, and accounted for 241 cases in 2019.[13]Centers for Disease Control and Prevention. Waterborne disease and outbreak surveillance reporting: giardiasis NNDSS summary report for 2019. May 2024 [internet publication].
https://www.cdc.gov/healthy-water-data/documentation/giardiasis-nndss-summary-report-for-2019.html
However, there is wide variation in surveillance efforts in the US; one analysis noted that at least 4 states, and up to 9 states, did not participate in giardiasis case reporting during the period 1995-2016.[14]Coffey CM, Collier SA, Gleason ME, et al. Evolving epidemiology of reported Giardiasis cases in the United States, 1995-2016. Clin Infect Dis. 2021 Mar 1;72(5):764-770.
https://www.doi.org/10.1093/cid/ciaa128
http://www.ncbi.nlm.nih.gov/pubmed/32047932?tool=bestpractice.com
Those most likely to acquire giardiasis include:[1]Center for Disease Control and Prevention. CDC Yellow Book 2024: health information for international travel. Section 5: travel-associated infections & diseases - giardiasis. May 2023 [internet publication].
https://wwwnc.cdc.gov/travel/yellowbook/2024/infections-diseases/giardiasis
[14]Coffey CM, Collier SA, Gleason ME, et al. Evolving epidemiology of reported Giardiasis cases in the United States, 1995-2016. Clin Infect Dis. 2021 Mar 1;72(5):764-770.
https://www.doi.org/10.1093/cid/ciaa128
http://www.ncbi.nlm.nih.gov/pubmed/32047932?tool=bestpractice.com
[15]Conners EE, Miller AD, Balachandran N, et al. Giardiasis outbreaks - United States, 2012-2017. MMWR Morb Mortal Wkly Rep. 2021 Mar 5;70(9):304-7.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948938
[16]Reses HE, Gargano JW, Liang JL, et al. Risk factors for sporadic Giardia infection in the USA: a case-control study in Colorado and Minnesota. Epidemiol Infect. 2018 Jul;146(9):1071-8.
https://www.cambridge.org/core/journals/epidemiology-and-infection/article/risk-factors-for-sporadic-giardia-infection-in-the-usa-a-casecontrol-study-in-colorado-and-minnesota/63B6FA03D86700897DFEA5473695A217
http://www.ncbi.nlm.nih.gov/pubmed/29739483?tool=bestpractice.com
[17]Centers for Disease Control and Prevention. Giardia: about Giardia infections. May 2024 [internet publication].
https://www.cdc.gov/giardia/about/index.html
Children less than 4 years of age
Individuals in contact with children in diapers
Individuals drinking water from, or swimming in a, river, lake, or stream (e.g., campers, hunters, backpackers)
International travelers
Tourists to endemic areas
Travel destinations with higher risk include: Africa (North Africa and sub-Saharan Africa), the Caribbean, Central and South America, South-Central Asia, Eastern Europe, and the Middle East.[1]Center for Disease Control and Prevention. CDC Yellow Book 2024: health information for international travel. Section 5: travel-associated infections & diseases - giardiasis. May 2023 [internet publication].
https://wwwnc.cdc.gov/travel/yellowbook/2024/infections-diseases/giardiasis
In adults, exposure risks may vary between men and women, and males may be at greater risk of infection.[14]Coffey CM, Collier SA, Gleason ME, et al. Evolving epidemiology of reported Giardiasis cases in the United States, 1995-2016. Clin Infect Dis. 2021 Mar 1;72(5):764-770.
https://www.doi.org/10.1093/cid/ciaa128
http://www.ncbi.nlm.nih.gov/pubmed/32047932?tool=bestpractice.com
[18]Laupland KB, Church DL. Population-based laboratory surveillance for Giardia sp. and Cryptosporidium sp. infections in a large Canadian health region. BMC Infect Dis. 2005 Sep 16;5:72.
https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-5-72
http://www.ncbi.nlm.nih.gov/pubmed/16168061?tool=bestpractice.com