Complications

Complication
Timeframe
Likelihood
short term
medium

Profuse watery diarrhea can lead to profound dehydration in some situations due to parasite-induced damage to intestinal brush border and secretion of fluid due to increased permeability of small-intestinal epithelial cells. Infants and pregnant women are particularly at risk.[72]

short term
medium

Even in asymptomatic patients, 10% to 20% of body weight can be lost due to malabsorption of fats, sugars, carbohydrates, and vitamins.

Described nutritional deficiencies include fat-soluble vitamins, vitamin B12, folate, protein and amino acids, and D-xylose and disaccharides.[4][7]​​ Hypoalbuminemia and secondary lactase deficiency may also occur.

short term
medium

Occurs in 20% to 40% of patients.​ This syndrome may take several weeks to resolve. Thus, a trial of avoiding lactose-containing foods and liquids should be instituted if the stool is negative for G duodenalis.

Postinfectious irritable bowel syndrome is also common.

short term
low

Rash, urticaria, aphthous ulceration, retinal arteritis, uveitis, and reactive arthritis or synovitis may be seen.[7]​​[8] These are thought to be due to inflammation and induction of type 2 immune response. Delayed-type immune reaction may also play a role.

short term
low

Spread from the duodenum to the biliary and pancreatic ducts has been reported.[90][91]

Aspiration of biliary contents by endoscopic retrograde cholangiography is a helpful aid to diagnosis and therapy.

short term
low

A form of follicular hyperkeratosis associated with vitamin A and C deficiency or deficiency of essential fatty acids.[92]

Requires treatment of giardiasis and appropriate nutritional support.

long term
medium

Population-level studies in low- and middle-income countries report a relationship with chronic giardia detection and effects on growth and development in children.[10][88][89]

Faltering growth

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