Primary biliary cholangitis

American Association for the Study of Liver Diseases[14]Lindor KD, Bowlus CL, Boyer J, et al. Primary biliary cholangitis: 2018 practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2019 Jan;69(1):394-419. https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.30145 http://www.ncbi.nlm.nih.gov/pubmed/30070375?tool=bestpractice.com ​

The diagnosis of PBC can be established when two of the following three criteria are met:

• Biochemical evidence of cholestasis based on alkaline phosphatase elevation.

• Presence of antimitochondrial antibody (AMA), or other PBC-specific autoantibodies, including sp100 or gp210, if AMA is negative.

• Histologic evidence of nonsuppurative destructive cholangitis and destruction of interlobular bile ducts.