Complications
This usually is a rate-related phenomenon associated with the infusion of Fab minutes after infusion is started. A membrane filter will reduce the risk of a reaction. If the reaction occurs, the infusion needs to be stopped and restarted at a slower rate.
Atrial fibrillation (AF) occurs at a median of 7 days after therapy with Fab, affecting about 2% of treated patients in one study.[49] Patients who have been treated with Fab are monitored for development of uncontrolled AF or worsening heart failure and given additional treatment as required.
There have been reported cases of patients who had cardiac arrest with prolonged resuscitation who received digoxin immune Fab after the arrest and recovered.[31]
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