The number of people living with dementia worldwide almost tripled from 20.2 million in 1990 to more than 55 million in 2023, according to the World Health Organization (WHO), and there are nearly 10 million new cases each year.[4]World Health Organization. Dementia. Mar 2023 [internet publication].
https://www.who.int/news-room/fact-sheets/detail/dementia
[5]GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 Jan;18(1):88-106.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291454
http://www.ncbi.nlm.nih.gov/pubmed/30497964?tool=bestpractice.com
This increase has largely been attributed to population aging and population growth. The number of people living with dementia is expected to reach over 152 million by 2050.[6]GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019. Lancet Public Health. 2022 Feb;7(2):e105-25.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810394
http://www.ncbi.nlm.nih.gov/pubmed/34998485?tool=bestpractice.com
Vascular dementia is estimated to account for about 17% of all dementia, with Alzheimer disease accounting for about 70%, but there is considerable overlap.[7]Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1-2):125-32.
http://www.ncbi.nlm.nih.gov/pubmed/17975326?tool=bestpractice.com
[8]Braffman BH, Zimmerman RA, Trojnowski JQ, et al. Brain MR: pathologic correlation with gross and histopathology. II. Hyperintense white matter foci in the elderly. AJR Am J Roentgenol. 1988 Sep;151(3):559-66.
https://www.ajronline.org/doi/pdf/10.2214/ajr.151.3.559
http://www.ncbi.nlm.nih.gov/pubmed/3261518?tool=bestpractice.com
[9]De Reuck J, Deramecourt V, Cordonnier C, et al. The incidence of post-mortem neurodegenerative and cerebrovascular pathology in mixed dementia. J Neurol Sci. 2016 Jul 15;366:164-6.
http://www.ncbi.nlm.nih.gov/pubmed/27288798?tool=bestpractice.com
[10]Perneczky R, Tene O, Attems J, et al. Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group. BMC Med. 2016 Nov 3;14(1):162.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093932
http://www.ncbi.nlm.nih.gov/pubmed/27806707?tool=bestpractice.com
The incidence of vascular dementia has been estimated at approximately 3.8 per 1000 per annum. The estimated incidence in people ages between 65 and 69 years is between 0.3 and 2.2 per 1000 per annum, and this rises with age to between 9.3 and 15.9 per 1000 per annum in those ages >90 years.[11]Bowler JV. Modern concept of vascular cognitive impairment. Br Med Bull. 2007;83:291-305.
http://www.ncbi.nlm.nih.gov/pubmed/17675645?tool=bestpractice.com
In the US, this represents a prevalence of 332,000 to 856,000 patients affected.[7]Plassman BL, Langa KM, Fisher GG, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29(1-2):125-32.
http://www.ncbi.nlm.nih.gov/pubmed/17975326?tool=bestpractice.com
Estimates of incidence and prevalence are likely to vary depending on the criteria used.
Men are more likely to develop vascular dementia than women (unlike Alzheimer disease, where women are at increased risk).[12]Hagnell O, Franck A, Grasbeck A, et al. Vascular dementia in the Lunby study: 1. a prospective, epidemiological study of incidence and risk from 1957-1972. Neuropsychobiology. 1992;26(1-2):43-9.
http://www.ncbi.nlm.nih.gov/pubmed/1475037?tool=bestpractice.com
Higher rates of all-cause dementia have been reported in Asian and black populations, and with younger age at time of diagnosis, both in the US and around the world. Area-level deprivation has also been shown to be independently associated with an increased risk of dementia in a dose-dependent manner.[13]Gorelick PB, Brody JA, Cohen DC, et al. Risk factors for dementia associated with multiple cerebral infarcts: a case-control analysis in predominantly African-American hospital-based patients. Arch Neurol. 1993 Jul;50(7):714-20.
http://www.ncbi.nlm.nih.gov/pubmed/8323474?tool=bestpractice.com
[14]Mehta KM, Yeo GW. Systematic review of dementia prevalence and incidence in United States race/ethnic populations. Alzheimers Dement. 2017 Jan;13(1):72-83.
http://www.ncbi.nlm.nih.gov/pubmed/27599209?tool=bestpractice.com
[15]Bothongo PLK, Jitlal M, Parry E, et al. Dementia risk in a diverse population: a single-region nested case-control study in the East End of London. Lancet Reg Health Eur. 2022 Apr;15:100321.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9088197
http://www.ncbi.nlm.nih.gov/pubmed/35558994?tool=bestpractice.com