Last reviewed: 19 Mar 2025
Last updated: 18 Feb 2025
Summary
Definition
History and exam
Risk factors
- infants and young children
- young adults
- older people
- summer and fall
- exposure to mosquito or tick vector
- unvaccinated for mumps
- use of swimming pools and ponds
- immunosuppression
- exposure to rodents
Diagnostic tests
1st tests to order
- CSF microscopy
- CSF Gram stain
- CSF bacterial culture
- CSF protein
- CSF glucose
- CSF PCR for enteroviruses
- CSF PCR for herpes viruses
- HIV serology/HIV reverse transcriptase (RT)-PCR
Treatment algorithm
Contributors
Expert advisers
John Williams, MRCP, DTM&H
Consultant
The James Cook University Hospital
Middlesbrough
UK
Disclosures
JW declares that he has no competing interests.
Acknowledgements
Dr John Williams would like to gratefully acknowledge Dr David Chadwick, a previous contributor to this topic.
Disclosures
DC is an author of a reference cited in this topic.
Peer reviewers
Karen Roos, MD
John and Nancy Nelson Professor of Neurology
Indiana University School of Medicine
Indianapolis
IN
Disclosures
KR declares that she has no competing interests.
Vassiliki Syriopoulou, MD
Professor of Pediatrics
University of Athens
Aghia Sophia Children's Hospital
Athens
Greece
Disclosures
VS declares that she has no competing interests.
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