When viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflects the latest evidence-based guidance.

Last reviewed: 18 Mar 2025
Last updated: 20 Mar 2025

Summary

Definition

History and exam

Key diagnostic factors

  • nausea
  • vomiting
  • diarrhea
  • abdominal pain

Other diagnostic factors

  • malaise
  • anorexia
  • fever
  • volume depletion

Risk factors

  • exposure to contaminated food or water sources
  • close contact with infected people
  • poor hygiene
  • older age
  • HIV infection
  • organ transplantation
  • chronic illness

Diagnostic tests

Tests to consider

  • basic metabolic profile
  • renal function
  • stool rapid antigen testing
  • stool reverse transcriptase polymerase chain reaction (RT-PCR) or multiplex PCR
  • stool viral culture
  • stool electron microscopy
  • stool for culture, ova, and parasites

Treatment algorithm

Contributors

Expert advisers

Ali Hassoun, MD, FACP, FIDSA, AAHIVS

Infectious Disease Specialist

Alabama Infectious Diseases Center

Huntsville

AL

Disclosures

AH declares that he has no competing interests.

Acknowledgements

Dr Ali Hassoun would like to gratefully acknowledge Dr Kyle E. Brown, Dr Easwaran Variyam, Dr Robert Schiller, Dr Srikrishna Nagri, and Dr Sury Anand, the previous contributors to this topic.

Disclosures

KEB, EV, RS, SN, and SA declare that they have no competing interests.

Peer reviewers

Alexandre R. Marra, MD

Department of Infectious Diseases

Universidade Federal de São Paulo

São Paulo

Brazil

Disclosures

ARM declares that he has no competing interests.

Use of this content is subject to our disclaimer