Complications

Complication
Timeframe
Likelihood
variable
high

Undiagnosed or untreated MOH may cause frequent or daily headache or worsening of headache, including increased frequency, intensity, and headache-related disability.[10]

variable
high

Organ damage can occur depending on the medication that is overused. For example:

  • Overuse of acetaminophen may cause liver toxicity

  • Overuse of a nonsteroidal anti-inflammatory drug (NSAID) may lead to kidney injury

  • Overuse of opioids may induce respiratory suppression or hyperalgesia

  • Overuse of triptans or ergot derivatives may be associated with cardiovascular adverse effects.

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