Epidemiology

​The prevalence of POTS is estimated to be between 0.1% and 1%, although the data are unclear.​[1][3]​​[4][8]​​[9]

It is more common in women than men, with a female to male ratio of 4:1.[1][2][8]​ Most patients who present with POTS are typically young women ages 15 to 25 years.[2][10]​​ POTS can occur outside of this age range, but new onset POTS is rare after age 50.[2]​ Patients <12 years may present with similar symptoms to older patients, particularly if there is a family history of POTS.[1]​ However, POTS remains undefined in patients <12 years and the sensitivity and specificity of the heart rate criteria in this age group is not established.[1]​

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