Patient discussions
Adherence to treatment is important and should be encouraged. Calcium should be taken in divided doses with food. Tight adherence to dietary guidelines regarding high calcium but low phosphorus intake is important. The dietary prescription needs to be tailored to the age of the patient, the severity of the calcium and phosphorus defects, and the ability to tolerate oral calcium.[55][57] Patients should be encouraged to cease smoking.
If a patient with pseudohypoparathyroidism would like to conceive, preimplantation genetic diagnosis (PGD) should be considered to decrease and potentially eliminate the transmission of GNAS mutation to the fetus. PGD allows the selection of embryos without GNAS mutations for implantation.[58]
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