Discoid lupus erythematosus

Test

Should be performed in all patients presenting with DLE lesions to detect progression to systemic lupus erythematosus (SLE) as early as possible.

Antinuclear antibody (ANA) titer is low in 30% to 40% of patients.

High-titer ANA, anti-dsDNA antibodies, and anti-ribonucleoprotein antibodies may suggest SLE or overlapping connective tissue disease. Anti-Ro (SS-A) antibodies can occasionally be found in patients with DLE, while anti-La (SS-B) antibodies are distinctly unusual in patients with isolated DLE.

Test

Should be performed in all patients presenting with DLE lesions.

Although typically normal, a few patients may have mild leukopenia. Modest to severe leukopenia may suggest underlying systemic lupus erythematosus.

Test

Should be performed in all patients presenting with DLE lesions.

Moderate or marked elevation is more likely to be associated with active systemic lupus erythematosus or underlying infection.

Test

Should be performed in all patients presenting with DLE lesions to exclude any systemic involvement, particularly renal impairment, associated with systemic lupus erythematosus.

Test

Should be performed in all patients presenting with DLE lesions to exclude any systemic involvement, particularly renal impairment, associated with systemic lupus erythematosus.

Test

Confirms diagnosis. Usually indicated if the diagnosis is in doubt. [Figure caption and citation for the preceding image starts]: Skin biopsy showing hyperkeratosis, thinning of the epidermis, degeneration of the basal layer of the epidermis (arrow), and a predominantly lymphocytic inflammatory cell infiltrate in the dermisFrom the collection of Dr K. Blessing, used with permission [Citation ends].