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Last reviewed: 23 Mar 2025
Last updated: 12 Sep 2023

Summary

Definition

History and exam

Key diagnostic factors

  • dyspnea
  • syncope
  • dizziness
  • CHF/pulmonary edema
  • embolic manifestations
  • systolic or diastolic murmur
  • tumor plop

Other diagnostic factors

  • weight loss
  • fatigue
  • fever
  • pallor
  • arthralgia
  • Raynaud phenomenon
  • loud first heart sound
  • opening snap
  • Carney complex
  • intracerebral aneurysm

Risk factors

  • family history of atrial myxoma
  • female sex
  • age 40-60 years

Diagnostic tests

1st tests to order

  • echocardiogram
  • ECG
  • CBC
  • CXR

Tests to consider

  • erythrocyte sedimentation rate
  • C-reactive protein
  • protein electrophoresis
  • CT scan (chest)
  • MRI scan (chest)
  • biopsy

Treatment algorithm

Contributors

Authors

Syed Wamique Yusuf

Professor of Medicine

Department of Cardiology

University of Texas MD Anderson Cancer Center

Houston

TX

Disclosures

SWY declares that he has no competing interests.

Dr Syed Wamique Yusuf would like to gratefully acknowledge the assistance of Dr Daniel J. Lenihan.

Disclosures

DJL declares that he has no competing interests.

Peer reviewers

Associate Professor of Medicine

Stanford University

Stanford

CA

Disclosures

PH declares that he has no competing interests.

Chief

Cardiology Service

Memorial Sloan-Kettering Cancer Center

New York

NY

Disclosures

RS declares that he has no competing interests.

Integrated Lead Cardiologist

Western Sussex Hospitals NHS Trust and Cardiac Department

Worthing Hospital

Worthing

UK

Disclosures

BK declares that he has no competing interests.

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