Premature ovarian failure

Patient outlook

POF can occasionally be characterized by intermittent spontaneous restoration of ovarian function, particularly in the early stages of the disease, but in general, the disease course is not reversible. Women diagnosed with this condition are at increased risk of osteoporosis, cognitive impairment, and cardiovascular comorbidity.[33]Hamoda H; British Menopause Society and Women’s Health Concern. The British Menopause Society and Women's Health Concern recommendations on the management of women with premature ovarian insufficiency. Post Reprod Health. 2017;23(1):22-35. http://www.ncbi.nlm.nih.gov/pubmed/28381102?tool=bestpractice.com [38]The North American Menopause Society Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause. 2022 Jul 1;29(7):767-94. http://www.ncbi.nlm.nih.gov/pubmed/35797481?tool=bestpractice.com ​​ If treated appropriately with hormone replacement therapy until age 50, and with careful screening and management for associated autoimmune disorders, women with a diagnosis of POF can expect healthy long-term outcomes. Additionally, successful pregnancies can be achieved with utilization of donor oocytes and assisted reproductive technologies.