Differentials
Tension-type headache (TTH)
SIGNS / SYMPTOMS
Frequently coexists with migraine in the same patient.[57]
TTH is common, but rarely causes patients to seek medical care, unless it is very frequent and severe. Patients diagnosed with TTH in primary care may have migraine.
Attacks are generalized throughout the head; often bilateral pressure-like and nonthrobbing pain.[58] Often described as feeling like a tight band around the head.
Unlike with migraine, symptoms of TTH are not aggravated by physical activity.[39]
Tension headaches rarely have photophobia or phonophobia (and cannot have both; otherwise it is a migraine).[3]
The distinction is best made by taking a careful history and having the patient keep a diagnostic headache diary.
INVESTIGATIONS
There are no differentiating tests.
Cluster headache
SIGNS / SYMPTOMS
Cluster headache is rare. It is more common in men; by contrast, migraine is more common in women.[59]
Cluster headache causes extremely severe pain around only one eye, becomes maximally severe in a few minutes, and does not switch side.
Attacks last up to 3 hours (differentiating feature as migraine can last 4-72 hours) and cause restlessness and agitation (in contrast with migraine, where pain often worsens with routine physical activity), with autonomic signs or symptoms on the side of the pain.[3]
Cluster attacks can occur up to 8 times per day, with intervals of no headache between attacks.[3]
The cluster period usually lasts for several weeks, and often occurs at the same time during the year. Attacks may occur at exactly the same time of the day or night, especially during rapid eye movement sleep.[60]
The distinction is best made by taking a careful history and having the patient keep a diagnostic headache diary.
Cluster headache may occur in patients with migraine. The very short duration of headache relative to migraine, combined with several attacks per day, and restlessness during an attack, differentiates migraine and cluster headache.
INVESTIGATIONS
There are no differentiating tests.
Medication overuse headache
SIGNS / SYMPTOMS
This headache has a mixed picture of both migraine and tension-type features. It occurs on 15 days/month or more in a patient with a pre-existing headache disorder.[3] It may develop from overuse of acute medication to treat migraine attacks.[39]
Can be globalized and associated with nausea. Characterized by regular medication overuse for at least 3 months.[3]
Because they are available without a prescription, over-the-counter nonsteroidal anti-inflammatory drugs and aspirin, especially aspirin/acetaminophen/caffeine combinations, are common causes of medication-overuse headache.
INVESTIGATIONS
There are no differentiating tests.
Headache after head or neck trauma
SIGNS / SYMPTOMS
Post-traumatic headaches can mimic most forms of primary headache, including migraine.
In a patient with a prior history of migraine, worsening of headache in response to head trauma is considered to be an aggravation of migraine.
Diagnosis is made on the basis of the history. Post-traumatic headache is diagnosed only when a new type of headache begins for the first time within 7 days of head or neck injury.[3]
INVESTIGATIONS
There are no differentiating tests.
Subarachnoid hemorrhage (SAH)
SIGNS / SYMPTOMS
SAH is commonly a severe, sudden-onset headache (thunderclap headache), although up to 50% of patients may have a prodrome of a lower-grade "sentinel" headache.[61]
As with migraine, analgesics or triptans may improve the pain.[62]
The physical examination may be normal, although up to 25% of patients have neurologic findings.[61]
Cerebral neoplasm
SIGNS / SYMPTOMS
While headache is a common symptom in patients with cerebral neoplasms, it has no consistent characteristics and rarely occurs in the absence of other suspicious historical or examination features.
Suspicion is increased in patients with a progressive pattern of headache worsening in conjunction with the development of new neurologic signs or symptoms.
Papilledema on fundoscopic examination should prompt consideration of a neoplastic or other cause of high cerebrospinal fluid pressure.[63]
INVESTIGATIONS
CT or MRI scans may identify space-occupying lesions.
Low-pressure headache
SIGNS / SYMPTOMS
Headache attributed to low cerebrospinal fluid pressure is often worsened with standing and improved with lying down.[3]
It can result from a spontaneous or iatrogenic dural tear; for example, following craniotomy or epidural analgesia.
INVESTIGATIONS
The diagnosis of low-pressure headache can be very difficult if the dural tear occurred spontaneously. Lumbar puncture may show a low opening pressure, and MRI scans of the brain with gadolinium may demonstrate pachymeningeal enhancement.[64] Spinal myelogram with CT imaging may demonstrate contrast extravasation.[65]
High-pressure headache (idiopathic intracranial hypertension)
SIGNS / SYMPTOMS
Historical and physical examination features suggestive of headaches due to idiopathic intracranial hypertension include visual disturbances, tinnitus, and the finding of papilledema on ophthalmologic examination.
High cerebrospinal fluid pressure can result from intracranial pathology, such as cerebral neoplasms, or from idiopathic intracranial hypertension (IIH).[3]
IIH is most common in obese women of childbearing age and is also associated with the use of certain antibiotics and oral contraceptives.[66]
INVESTIGATIONS
Lumbar puncture (LP) may show a high opening pressure, but must not be done in the presence of papilledema until an imaging study has been performed. LP must be performed with the patient in an appropriate position (lateral decubitus), with careful measurement of cerebrospinal fluid pressure.[67]
Central nervous system (CNS) infection
SIGNS / SYMPTOMS
Headache is a common feature of CNS infections, and has no consistent clinical characteristics.
The diagnosis is straightforward in the presence of a high fever or altered consciousness. Indolent CNS infections, however, can be more difficult to diagnose.
Suspicion for these disorders should be increased in patients with immune compromise that predisposes to infection with Toxoplasma gondii, Cryptococcus, or cytomegalovirus.
INVESTIGATIONS
Culture and microscopy of cerebrospinal fluid and samples from other potential sites of infection may identify the infecting microorganism.
Giant cell arteritis
SIGNS / SYMPTOMS
Giant cell arteritis should be considered in patients over the age of 50 years with new-onset or worsening headache.
It is most common in people of northern European descent.[68]
If untreated, permanent visual loss can occur.
The headache has no characteristic features, but it commonly improves or disappears within 3 days of beginning high-dose corticosteroid treatment.[3]
Historical features include a history of jaw claudication, muscle pain, and a tender temporal artery.[45][68]
INVESTIGATIONS
Elevated erythrocyte sedimentation rate (>100 mm/hour) and/or elevated C-reactive protein is associated with giant cell arteritis; biopsy of temporal artery shows typical inflammatory infiltrate.[45] Ultrasound can detect pathologic changes in other cranial arteries than the temporal artery.[69]
Arterial dissection
SIGNS / SYMPTOMS
Headache and/or neck pain occurs in more than 50% of cases of cervical artery dissection. This is the most frequent initial symptom (33% to 86% of cases) and can occasionally be the only symptom. A severe acute migraine in the setting of neck pain may indicate an increased risk for cervical artery dissection, resulting in stroke.[70]
The headache has no consistent features, and can mimic primary headache disorders or present as a sudden, severe thunderclap headache.[71]
Headache is usually found on the same side as the dissection and can occur with Horner syndrome or tinnitus.[72]
INVESTIGATIONS
Angiography may demonstrate the lesion.
Cerebral venous thrombosis (CVT)
SIGNS / SYMPTOMS
Headache is the most common symptom (80% to 90% of cases) and the most common initial symptom in CVT.
The headache has no specific characteristics, can mimic any of the primary headache disorders, and can be a sudden-onset, severe thunderclap headache.[73]
In 90% of patients, CVT is associated with focal neurologic signs and evidence of idiopathic intracranial hypertension.[73]
INVESTIGATIONS
Neuroimaging (magnetic resonance venogram) is generally necessary for definitive diagnosis.[74]
Ischemic stroke
SIGNS / SYMPTOMS
Headache can be a symptom of ischemic stroke. Migraine, particularly with aura, is an independent risk factor for ischemic stroke, with highest risk in women ages under 45 years.[75]
Neurologic deficit in stroke or transient ischemic attack (TIA) is usually maximal at onset and lasts longer than an hour.[76]
Migraine aura can be confused with ischemic stroke or TIA, but typically develops gradually, consists of positive and negative symptoms with no relevant imaging abnormalities, and is fully reversible.[4]
INVESTIGATIONS
CT scans or MRI scans may detect ischemic lesions.
Reversible cerebral vasoconstriction syndrome (RCVS)
SIGNS / SYMPTOMS
RCVS is associated with repeated thunderclap headaches, rather than one prolonged severe headache as seen in migraine.[77]
RCVS causes short irregular segments of vasoconstriction in small arteries, in an asymmetric distribution. It is often associated with convexity subarachnoid hemorrhage, rather than basilar subarachnoid hemorrhages, and can be associated with ischemic stroke.[78]
INVESTIGATIONS
CT followed by lumbar puncture is used to rule out subarachnoid hemorrhage. MR angiography or CT angiography can visualize vasoconstriction in cerebral arteries.
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