Emerging treatments
Mycophenolate
Mycophenolate has been shown, in small uncontrolled studies, to be effective in patients with frequent relapses or who become prednisolone dependent.[34] Larger controlled studies are required to establish a role for mycophenolate in acute interstitial nephritis acute interstitial nephritis (AIN) management.
Infliximab
In a case series (n=10), the tumour necrosis factor (TNF)-alpha inhibitor infliximab was shown to result in improvement of kidney function in a subset of patients with corticosteroid-resistant AIN from immune checkpoint inhibitors.[35] Larger controlled studies are required to understand the role of infliximab in AIN treatment.
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