Essential thrombocythaemia

The development of AML is uncommon; the 15-year cumulative risk has been reported to be in the range of 2% to 5.3%.[70]Barbui T, Thiele J, Passamonti F, et al. Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. J Clin Oncol. 2011 Aug 10;29(23):3179-84. http://www.ncbi.nlm.nih.gov/pubmed/21747083?tool=bestpractice.com [71]Cerquozzi S, Tefferi A. Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors. Blood Cancer J. 2015 Nov 13;5:e366. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670948 http://www.ncbi.nlm.nih.gov/pubmed/26565403?tool=bestpractice.com [72]Passamonti F, Rumi E, Pungolino E, et al. Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. Am J Med. 2004 Nov 15;117(10):755-61. http://www.ncbi.nlm.nih.gov/pubmed/15541325?tool=bestpractice.com

Acute myeloid leukaemia

The development of myelofibrosis is uncommon; the 15-year cumulative risk has been reported to be in the range of 4% to 11%.[70]Barbui T, Thiele J, Passamonti F, et al. Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. J Clin Oncol. 2011 Aug 10;29(23):3179-84. http://www.ncbi.nlm.nih.gov/pubmed/21747083?tool=bestpractice.com [71]Cerquozzi S, Tefferi A. Blast transformation and fibrotic progression in polycythemia vera and essential thrombocythemia: a literature review of incidence and risk factors. Blood Cancer J. 2015 Nov 13;5:e366. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670948 http://www.ncbi.nlm.nih.gov/pubmed/26565403?tool=bestpractice.com [72]Passamonti F, Rumi E, Pungolino E, et al. Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. Am J Med. 2004 Nov 15;117(10):755-61. http://www.ncbi.nlm.nih.gov/pubmed/15541325?tool=bestpractice.com

Myelofibrosis

Thrombosis is related to both qualitative and quantitative platelet alterations. Thrombotic events may include stroke, transient ischaemic attacks, retinal artery or venous occlusions, coronary artery occlusion, pulmonary embolism, hepatic or portal vein thrombosis, deep vein thrombosis, and digital ischaemia.[6]Elliott MA, Tefferi A. Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia. Br J Haematol. 2005 Feb;128(3):275-90. https://www.doi.org/10.1111/j.1365-2141.2004.05277.x http://www.ncbi.nlm.nih.gov/pubmed/15667529?tool=bestpractice.com ​​

Associated with extreme thrombocytosis.

May complicate pregnancy.​[10]Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: overview and practice recommendations. Am J Hematol. 2021 Mar 1;96(3):354-66. https://www.doi.org/10.1002/ajh.26067 http://www.ncbi.nlm.nih.gov/pubmed/33296529?tool=bestpractice.com ​

May complicate pregnancy.​[10]Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: overview and practice recommendations. Am J Hematol. 2021 Mar 1;96(3):354-66. https://www.doi.org/10.1002/ajh.26067 http://www.ncbi.nlm.nih.gov/pubmed/33296529?tool=bestpractice.com ​

May complicate pregnancy.​[10]Gangat N, Tefferi A. Myeloproliferative neoplasms and pregnancy: overview and practice recommendations. Am J Hematol. 2021 Mar 1;96(3):354-66. https://www.doi.org/10.1002/ajh.26067 http://www.ncbi.nlm.nih.gov/pubmed/33296529?tool=bestpractice.com [73]Griesshammer M, Heimpel H, Pearson TC. Essential thrombocythemia and pregnancy. Leuk Lymphoma. 1996 Sep;22(suppl 1):57-63. http://www.ncbi.nlm.nih.gov/pubmed/8951773?tool=bestpractice.com