Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- pruritus
- xerosis (dry skin)
- sites of skin involvement
Other diagnostic factors
- erythema
- scaling
- vesicles
- papules
- keratosis pilaris
- excoriations
- lichenification
- hypopigmentation
Risk factors
- filaggrin gene mutation
- age <5 years
- family history of eczema
- allergic rhinitis
- asthma
- active and passive exposure to smoke
- female sex
- African-American ethnicity
Diagnostic investigations
Investigations to consider
- IgE levels
- skin-prick testing
- oral food challenge
- trial elimination diet
- patch testing
- skin biopsy
Treatment algorithm
Contributors
Authors
Adelaide A. Hebert, MD
Professor & Director of Pediatric Dermatology
Clinical Specialist
Department of Dermatology and Pediatrics
University of Texas Health Sciences Center at Houston
Houston
TX
Disclosures
AAH has received research grants paid to UTHealth McGovern Medical School Houston from Pfizer, GSK, Dermavant, Arcutis, and Novan; has received honoraria from Pfizer, Verrica, and Novan; and is on the data safety monitoring boards for GSK, Ortho Dermatologics, and Regeneron-Sanofi.
Alexander Jafari, MD
Dermatology Clinical Research Fellow
Department of Dermatology
University of Texas Health Science Center at Houston
Houston
TX
Disclosures
AJ declares that he has no competing interests.
Matthew Dallo, MD
Clinical Research Fellow
Department of Dermatology
University of Texas Health Science Center at Houston
Houston
TX
Disclosures
MD declares that he has no competing interests.
Acknowledgements
Dr Adelaide A. Hebert, Alexander Jafari, and Dr Matthew Dallo would like to gratefully acknowledge Dr Eugenio G. Galindo, Dr Quoc-Bao D. Nguyen, Dr Mary D. DarConte, Dr Christina M. Gelbard, and Dr Daniel A. Grabella, previous contributors to this topic.
Disclosures
EGG, QBDN, MDD, CMG, and DAG declare that they have no competing interests.
Peer reviewers
Amor Khachemoune, MD
Assistant Professor
New York University School of Medicine
NY
Disclosures
AK declares that he has no competing interests.
John English, MBBS, FRCP
Consultant Dermatologist
Department of Dermatology
Queen's Medical Centre
Nottingham University Hospitals
Nottingham
UK
Disclosures
JE declares that he has no competing interests.
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