Differentials
Common
Migraine headache
History
positive family history of migraine; symptoms may be unilateral or pulsing; pain moderate or severe, aggravated by physical activity; may be associated with nausea, vomiting, photophobia, or phonophobia; may occur with an aura[20]
Exam
normal
1st investigation
- none:
diagnosis is clinical, and imaging is not routinely recommended
Acute sinusitis
History
frontal headache; purulent nasal discharge; facial pain and congestion; fever, cough, headache, fatigue, dental pain, ear pain or fullness
Exam
nasal obstruction, halitosis, facial tenderness
1st investigation
- none:
diagnosis is clinical, and imaging is not routinely recommended
Other investigations
- sinus CT:
sinus thickening; bony erosions
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Uncommon
Subarachnoid haemorrhage
History
rapid onset of severe headache often described as 'worst headache of my life'
Exam
may be associated with altered consciousness, meningeal signs, or focal signs; may be no physical findings
1st investigation
- non-contrast head CT:
bright (hyperdense) signal is consistent with an acute bleed; typically a full appearance of the brain with loss of basal cisterns
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Ischaemic stroke
History
acute onset of headache; focal seizures; symptoms of elevated intracranial pressure (headache, vomiting, depressed consciousness)
Exam
focal neurological signs, focal seizures, altered consciousness
1st investigation
- non-contrast head CT:
bright (hyperdense) signal is consistent with an acute bleed; CT may identify large or older ischaemic strokes
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Other investigations
- MRI or MR angiography (MRA):
multiple subcortical areas of ischaemia suggests embolic source; MRA may demonstrate an arteriovenous malformation or fistula; MRI (with diffusion weighted imaging) will identify strokes earlier than CT
More - hypercoagulability testing:
may be abnormal
- ECG:
may reveal a cardiac cause
More - echocardiography:
may reveal a cardiac cause
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Parenchymal haemorrhage
History
abrupt onset of headache (thunderclap headache), altered mental status (suggestive of elevated intracranial pressure), may be history of trauma, may be related to vascular malformations (AVM), may be history of hypertension
Exam
altered mental status may suggest diffuse cerebral involvement or haemorrhage within the reticular activating system, or may suggest elevated intracranial pressure; focal neurological signs relate to the location of the haemorrhage
1st investigation
- non-contrast head CT:
bright (hyperdense) signal is consistent with acute blood
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Other investigations
Vascular dissection (carotid, vertebral, or intracranial arteries)
History
may be history of head or neck injury, the injury may be mild or considered insignificant, and the onset of symptoms may be delayed; presents with headache and neck pain, with or without focal neurological symptoms due to secondary stroke or transient ischaemic attack
Exam
focal neurological signs are consistent with a secondary stroke (hemiplegia with carotid dissections and hemiataxia with vertebral artery dissections); neck auscultation may reveal bruits; Horner's syndrome (mild ptosis, anhidrosis, and miosis) is consistent with carotid injury
1st investigation
- MRI or MR angiography (MRA) of the head and neck:
crescentric hyperintense intramural haematoma within the vessel wall on axial fat saturated T1 sequences; may show an arterial cut-off; diffusion-weighted imaging demonstrates areas of infarction
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Other investigations
- angiography:
segmental tapering narrowing
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Cerebral sinovenous thrombosis
History
gradual onset of headache made worse by bending over or squatting, or while straining with bowel movements (Valsalva); vision changes common (e.g., blurring, horizontal double vision, peripheral vision constriction, and transient visual obscurations); pulsatile tinnitus possible; fever may be present
Exam
meningismus and/or mastoid tenderness or swelling; focal or non-focal neurological findings; optic nerve oedema; bilateral ocular abduction limitation
1st investigation
- neuroimaging:
hyperdense venous sinuses, haemorrhage, and areas of hypodense brain parenchyma
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Other investigations
- FBC:
possible polycythaemia
- PT and activated PTT:
hypercoagulable state
Postconcussion headache
History
history of trauma; confusion; altered concentration, memory, and problem solving; irritability; emotional changes; headaches may take several months to resolve
Exam
non-focal findings, except for mild alterations in mental status
1st investigation
- none:
diagnosis is clinical, and imaging is not routinely recommended
Other investigations
- non-contrast head CT:
intracranial abnormality, skull fracture
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Cerebral contusion
History
history of trauma; confusion or personality change; focal seizures; headaches may recur with exertion weeks after the inciting event
Exam
focal neurological findings, altered level of consciousness, or abnormal mental status testing
1st investigation
- non-contrast head CT:
dark (hypodensity) if oedema or bright (hyperdense) if haemorrhagic
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Other investigations
- MRI:
FLAIR (fluid-attenuated inversion recovery) hyperintensity consistent with oedema; T2 gradient echo sequences show hypointensity consistent with haemorrhage and may 'bloom' over time
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Subdural haemorrhage
History
usually occurs after head trauma; may be lucid intervals between the trauma and the onset of symptoms, which may develop quite slowly (because often due to a venous bleed) and include headache, seizures, and symptoms related to elevated intracranial pressure (vomiting and nausea)
Exam
focal findings on examination, focal seizures, altered level of consciousness, or coma
1st investigation
- non-contrast head CT:
bright (hyperdense) signal is consistent with an acute bleed
More
Other investigations
Intracranial hypotension
History
headache is generally diffuse and dull, worsens within 15 minutes of standing, and is associated with neck stiffness, tinnitus, hyperacusia, photophobia, and nausea; may be history of recent lumbar puncture or back/neck trauma; may be associated with Marfan's Syndrome, Ehlers-Danlos syndrome, neurofibromatosis, or polycystic kidney disease
Exam
abnormal hearing and photophobia; downward traction may lead to cranial nerve palsies or altered mental status, and may result in subdural hygromas or haematomas
1st investigation
- lumbar puncture with opening pressure:
opening pressure <60 mm H2O in sitting position
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Other investigations
- MRI with contrast:
diffuse pachymeningeal contrast enhancement, evidence of sagging brain, and sometimes subdural hygroma or haematoma
- CT myelogram:
may demonstrate diverticulum and localise leak
Epidural haemorrhage
History
usually history of head trauma; often a lucid interval between the trauma and the onset of headache; symptoms related to elevated intracranial pressure (vomiting and nausea); seizures
Exam
focal neurological findings, focal seizures, altered level of consciousness, or coma
1st investigation
- non-contrast head CT:
bright (hyperdense) signal is consistent with an acute bleed
More
Other investigations
Meningitis
History
acute onset of headache, fever, neck stiffness
Exam
positive meningeal signs (Kernig's and Brudzinski's signs), altered mental status
1st investigation
- lumbar puncture:
elevated WBCs and/or elevated protein
- MRI head without and with contrast, or CT head with contrast:
rules out haemorrhage and herniation
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Encephalitis
History
seizures; fever; exposure to infectious agent (e.g., arthropod-borne arboviruses such as eastern equine, western equine, St. Louis, Venezuelan equine encephalitis, and West Nile virus; herpes simplex type 1; lymphocytic choriomeningitis virus)
Exam
altered mental status ranging from minor deficits to complete unresponsiveness; focal motor or sensory neurological abnormalities; speech disorders; exaggerated deep tendon and/or pathological reflexes
1st investigation
- lumbar puncture:
elevated WBCs and/or elevated protein
- MRI head without and with contrast, or CT head with contrast:
rules out haemorrhage and herniation
More
Other investigations
- EEG:
generalised slowing or disorganisation are consistent with encephalopathy; rules out subclinical status epilepticus in the unconscious patient
More - fungal culture:
may be positive in immunocompromised patients
More - viral culture:
may identify causative virus
More - PCR:
may identify causative virus
More - serology:
may identify causative virus
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Dental caries, gingival disease, or abscess
History
pain typically localised to the mouth; may present as facial pain or headache
Exam
caries, gingival disease, abscess
1st investigation
- none:
diagnosis is clinical; patient should be referred for dental consultation
Other investigations
Brain tumour
History
indolent progressive headache, nausea or vomiting, difficult walking, visual symptoms, focal weakness, or personality change
Exam
optic nerve oedema, cranial nerve abnormalities, ataxia, abnormal reflexes, visual field or acuity defects
Temporomandibular disorders
History
temporomandibular joint pain, noise in the joint (clicking, popping, or crepitus with/without locking), masticatory muscle tenderness, limited mandibular movement;, headache in the temporal region, otalgia and/or tinnitus without a significant ear disorder; associated symptoms, such as myalgia and arthralgia, depression and anxiety may be present
Exam
pain may be triggered by jaw movement or pressure on the masticatory muscles, and may be associated with jaw click or reduced jaw movement; maximal mandibular opening is 35-55 mm, movement may be reduced to <35 mm; there may be an uncorrected deviation on maximum mouth opening; wear facets are indicative of bruxism
1st investigation
- none:
clinical diagnosis; requires dental referral
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Tension headache
History
often milder headache that is diffuse or posterior in location;[20] no associated migrainous features (nausea, vomiting, photophobia, phonophobia) or autonomic features
Exam
neurological examination is non-focal; trigger points may be identified in the neck
1st investigation
- none:
diagnosis is clinical, and imaging is not routinely recommended
Other investigations
Indometacin-responsive headache
History
unilateral, severe, boring headache lasting 20 minutes occurring 10 to 40 times per day with autonomic symptoms such as nasal congestion, lacrimation, and conjunctival injection; or unilateral headache lasting hours or days associated with milder autonomic or migrainous symptoms
Exam
non-focal neurological examination
1st investigation
- MRI with and without gadolinium:
normal
More
Other investigations
- indometacin trial:
headache improves quickly with indometacin administration
Medication overuse headache
History
drug history of ergotamine, triptans, analgesics, opioids, or a combination of these medications; headache has developed or markedly worsened during overuse; headache resolves or reverts to prior pattern within 2 months of discontinuation of overused medication
Exam
neurological examination is non-focal
1st investigation
- none:
diagnosis is clinical, and imaging is not routinely recommended
Other investigations
Cluster headache
History
stabbing excruciating headache, often at the orbit, that lasts 15 to 180 minutes and occurs 1 to 10 times per day, often daily for several days or weeks, then resolves for several weeks or months
Exam
neurological examination is non-focal; autonomic features are present, including lacrimation, conjunctival injection, nasal congestion, ptosis, and eyelid oedema
1st investigation
- MRI:
normal with cluster headache
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Other investigations
- oxygen supplementation:
resolution of headache
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New daily persistent headache
History
headache for more than 3 months that is unremitting and occurs daily from within 3 days of onset; mild to moderate intensity, bilateral in location, and not worsened by routine activity; may be migrainous features
Exam
neurological examination is non-focal
1st investigation
- MRI:
normal
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Other investigations
- lumbar puncture:
normal
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Intermittent hydrocephalus
History
intermittent severe headache
Exam
signs related to elevated intracranial pressure such as optic nerve oedema, abducens nerve palsy, or altered mental status may be present, but may not be present if obstruction is brief
1st investigation
- non-contrast head CT:
mass lesion may be present; hydrocephalus may be present
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Other investigations
- brain MRI with and without contrast:
mass lesion near the ventricular system
Pseudotumour cerebri (idiopathic intracranial hypertension)
History
headache made worse by bending over or squatting, or while straining with bowel movements (Valsalva); vision changes common (e.g., blurring, horizontal double vision, peripheral vision constriction, and transient visual obscurations); pulsatile tinnitus possible
Exam
non-focal examination findings; optic nerve oedema, bilateral ocular abduction
1st investigation
Other investigations
- MR or CT venogram with or without contrast:
venous outflow obstruction
More - MRI head with and without contrast:
may show secondary signs of increased intracranial pressure such as an empty sella, dilated optic sheaths, tortuous or enhancing optic nerves, and flattening of the posterior aspects of the globes
Ventriculoperitoneal shunt dysfunction
History
headache worse when supine; horizontal diplopia; history of trauma near track
Exam
new focal neurological signs; Cushing's triad of hypertension, bradycardia, and irregular breathing pattern; pupillary asymmetry; elevated intracranial pressure (altered mental status, horizontal diplopia, optic nerve oedema); evidence of disruption or tunnel infection (tenderness or erythema over the track); tenderness to abdominal palpation; ascites; acute abdomen (distal aetiology)
1st investigation
- non-contrast head CT:
shunt disconnection, malposition of the shunt catheter, or enlarged ventricles suggest shunt dysfunction
- shunt series x-rays:
imaging of the shunt in the neck, chest, and abdomen may reveal disconnection as the aetiology of malfunction
- neurosurgical evaluation and possible shunt tapping:
if a reservoir is present, measurement of pressure may be indicated
Other investigations
Pituitary apoplexy
History
headache that is often acute onset; visual impairment (often diplopia)
Exam
ophthalmoplegia, shock
1st investigation
- head and neck CT:
sellar or suprasellar hyperdense mass
Other investigations
Hypertensive encephalopathy
History
acute or gradual onset of decreased alertness, vision changes (blurring or obscuration), and seizures
Exam
examination may be limited by mental status change; hypertension
1st investigation
- head CT:
may show patchy bilateral areas of hypodensity with a posterior predominance
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Other investigations
Occipital neuralgia
History
posterior or calvarial headache, pain with neck/shoulder movement
Exam
tenderness over occipital condyles
1st investigation
- no initial test:
clinical diagnosis
Other investigations
Facial neuralgia
History
sudden lancinating unilateral facial pain
Exam
normal examination
1st investigation
- no initial test:
clinical diagnosis
Other investigations
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