Prognosis
The large majority of patients experience an acute febrile illness that generally resolves without sequelae. There is very little risk of recurrence in healthy individuals. However, up to 15% of children with roseola experience seizures. For example, in one series, 13% of children with roseola experienced seizures, which may be prolonged or recurrent.[12]
Following a primary infection, the virus becomes latent in peripheral blood mononuclear cells, and reactivation after solid-organ or bone marrow transplantation has been associated with morbidity.[23]
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