PP seen in early gestation may migrate into a normal position as pregnancy progresses. This is not true migration but rather differential growth at the upper end of the placenta compared with the lower. About 85% of placentas that are praevia at about 15 to 20 weeks and about one third that are praevia at 20 to 23 weeks will no longer be praevia at the onset of labour.[36]Dashe JS, McIntire DD, Ramus RM, et al. Persistence of placenta previa according to gestational age at ultrasound detection. Obstet Gynecol. 2002 May;99(5 Pt 1):692-7.
http://www.ncbi.nlm.nih.gov/pubmed/11978274?tool=bestpractice.com
[49]Oppenheimer L, Holmes P, Simpson N, et al. Diagnosis of low-lying placenta: can migration in the third trimester predict outcome? Ultrasound Obstet Gynecol. 2001 Aug;18(2):100-2.
http://www.ncbi.nlm.nih.gov/pubmed/11529986?tool=bestpractice.com
[50]Predanic M, Perni SC, Baergen RN, et al. A sonographic assessment of different patterns of placenta previa "migration" in the third trimester of pregnancy. J Ultrasound Med. 2005 Jun;24(6):773-80.
http://www.ncbi.nlm.nih.gov/pubmed/15914681?tool=bestpractice.com
[51]Olive EC, Roberts CL, Nassar N, et al. Test characteristics of placental location screening by transabdominal ultrasound at 18-20 weeks. Ultrasound Obstet Gynecol. 2006 Dec;28(7):944-9.
http://www.ncbi.nlm.nih.gov/pubmed/17121427?tool=bestpractice.com
[76]Becker RH, Vonk R, Mende BC, et al. The relevance of placental location at 20-23 gestational weeks for prediction of placenta previa at delivery: evaluation of 8650 cases. Ultrasound Obstet Gynecol. 2001 Jun;17(6):496-501.
https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1046/j.1469-0705.2001.00423.x
http://www.ncbi.nlm.nih.gov/pubmed/11422970?tool=bestpractice.com
Maternal prognosis
Maternal prognosis is generally good. Women who have an elective and urgent caesarean section are at risk of complications associated with this procedure.[77]Bergholt T, Stenderup JK, Vedsted-Jakobsen A, et al. Intraoperative surgical complication during cesarean section: an observational study of the incidence and risk factors. Acta Obstet Gynecol Scand. 2003 Mar;82(3):251-6.
https://obgyn.onlinelibrary.wiley.com/doi/full/10.1034/j.1600-0412.2003.00095.x
http://www.ncbi.nlm.nih.gov/pubmed/12694122?tool=bestpractice.com
Women with PP are at increased risk of receiving blood transfusion (because of preoperative, intra-operative, and postoperative bleeding) with the associated risks (which vary locally).[78]Magan EF, Evans S, Hutchinson M, et al. Postpartum hemorrhage after cesarean delivery: an analysis of risk factors. South Med J. 2005 Jul;98(7):681-5.
http://www.ncbi.nlm.nih.gov/pubmed/16108235?tool=bestpractice.com
Women are at increased risk of caesarean hysterectomy, although this risk remains low (0.2%).[79]Watanasomsiri N, Rungruxsrivorn T, Chaithongwongwatthana S. Risk factors for cesarean hysterectomy in cesarean delivery. J Med Assoc Thai. 2006 Oct;89 Suppl 4:S100-4.
http://www.ncbi.nlm.nih.gov/pubmed/17725146?tool=bestpractice.com
[80]Daskalakis G, Anastasakis E, Papantoniou, et al. Emergency obstetric hysterectomy. Acta Obstet Gynecol Scand. 2007 Feb;86(2):223-7.
https://obgyn.onlinelibrary.wiley.com/doi/full/10.1080/00016340601088448
http://www.ncbi.nlm.nih.gov/pubmed/17364287?tool=bestpractice.com
There is an increased risk of PP in subsequent pregnancies, although this risk remains low (<1%).[81]Yang Q, Wen SW, Oppenheimer L, et al. Association of caesarean delivery for first birth with placenta praevia and placental abruption in second pregnancy. BJOG. 2007 May;114(5):609-13.
http://www.ncbi.nlm.nih.gov/pubmed/17355267?tool=bestpractice.com
[82]Kennare, R, Tucker G, Heard A, et al. Risks of adverse outcomes in the next birth after a first cesarean delivery. Obstet Gynecol. 2007 Feb;109(2 Pt 1):270-6.
http://www.ncbi.nlm.nih.gov/pubmed/17267823?tool=bestpractice.com
Fetal prognosis
Fetal prognosis is generally good but may be compromised by excessive bleeding and intrauterine growth restriction.[83]Koifman A, Levy A, Zaulan Y, et al. The clinical significance of bleeding during the second trimester of pregnancy. Arch Gynecol Obstet. 2008 Jul;278(1):47-51.
http://www.ncbi.nlm.nih.gov/pubmed/18066562?tool=bestpractice.com
[84]Ananth CV, Demissie K, Smulian JC, et al. Relationship among placenta previa, fetal growth restriction, and preterm delivery: a population-based study. Obstet Gynecol. 2001 Aug;98(2):299-306.
http://www.ncbi.nlm.nih.gov/pubmed/11506849?tool=bestpractice.com
[85]Ananth CV, Smulian JC, Vintzileos AM. The effect of placenta previa on neonatal mortality: a population-based study in the United States, 1989 through 1997. Am J Obstet Gynecol. 2003 May;188(5):1299-304.
http://www.ncbi.nlm.nih.gov/pubmed/12748502?tool=bestpractice.com
Neonatal prognosis
Neonatal prognosis is dependent on the degree of prematurity along with the availability of specialist neonatal care.[85]Ananth CV, Smulian JC, Vintzileos AM. The effect of placenta previa on neonatal mortality: a population-based study in the United States, 1989 through 1997. Am J Obstet Gynecol. 2003 May;188(5):1299-304.
http://www.ncbi.nlm.nih.gov/pubmed/12748502?tool=bestpractice.com
[86]Salihu HM, Li QL, Rouse DJ, et al. Placenta previa: neonatal death after live births in the United States. Am J Obstet Gynecol. 2003 May;188(5):1305-9.
http://www.ncbi.nlm.nih.gov/pubmed/12748503?tool=bestpractice.com
[87]Lal AK, Hibbard JU. Placenta previa: an outcome-based cohort study in a contemporary obstetric population. Arch Gynecol Obstet. 2015 Aug;292(2):299-305.
http://www.ncbi.nlm.nih.gov/pubmed/25638449?tool=bestpractice.com
It is also affected by the degree of pre-delivery bleeding, which may cause neonatal anaemia.[83]Koifman A, Levy A, Zaulan Y, et al. The clinical significance of bleeding during the second trimester of pregnancy. Arch Gynecol Obstet. 2008 Jul;278(1):47-51.
http://www.ncbi.nlm.nih.gov/pubmed/18066562?tool=bestpractice.com
[84]Ananth CV, Demissie K, Smulian JC, et al. Relationship among placenta previa, fetal growth restriction, and preterm delivery: a population-based study. Obstet Gynecol. 2001 Aug;98(2):299-306.
http://www.ncbi.nlm.nih.gov/pubmed/11506849?tool=bestpractice.com
There may be a slight increase in the risk of sudden infant death syndrome.[88]Li DK, Wi S. Maternal placental abnormality and the risk of sudden infant death syndrome. Am J Epidemiol. 1999 Apr 1;149(7):608-11.
https://academic.oup.com/aje/article/149/7/608/167983
http://www.ncbi.nlm.nih.gov/pubmed/10192307?tool=bestpractice.com