Prognosis
Life expectancy
Hypopituitarism has been associated with a 1.8-fold higher mortality compared with an age- and sex-matched population.[3] Cardiovascular and cerebrovascular death rates are higher in patients with hypopituitarism compared with the normal population.[4] Growth hormone deficiency is potentially responsible for this increased mortality from cardiovascular disease, as it is associated with an atherogenic lipid profile and increased body fat, which are associated with an increased incidence of vascular disease.[3][70] However, it is likely that there is a multifactorial aetiology to excess mortality in these patients.[71] Age at diagnosis, female sex, and craniopharyngiomas were all significant independent risk factors for excess mortality in one study.[72]
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