Last reviewed: 10 Mar 2025
Last updated: 18 Jun 2024
Summary
Your Organisational Guidance
ebpracticenet urges you to prioritise the following organisational guidance:
Acute KeelpijnPublished by: Werkgroep Ontwikkeling Richtlijnen Eerste Lijn (Worel)Last published: 2017Mal de gorge aiguPublished by: Groupe de Travail Développement de recommmandations de première ligneLast published: 2017Definition
History and exam
Key diagnostic factors
- presence of risk factors
- child or adolescent age
- winter or spring season (in bacterial pharyngitis)
- summer/autumn season (in enteroviral pharyngitis)
- rhinorrhoea, nasal congestion, hoarseness, oral ulcers, and cough (in viral infection)
- sore throat
- pharyngeal exudate
- cervical adenopathy
- fever
- headache
- nausea, vomiting, and abdominal pain
- conjunctivitis
- maculopapular rash (in measles)
- Koplik spots (in measles)
- scarlatiniform rash (in group A Streptococcus [GAS] pharyngitis)
Other diagnostic factors
- sexual activity or abuse (in HIV, gonorrhoeal, or chlamydial infection)
- treatment failure of penicillin
- pharyngeal ulceration (in tularaemia)
- pharyngeal grey membrane (in diphtheria)
Risk factors
- nasal colonisation with group A Streptococcus (GAS)
- GAS-infected contact
- sexual activity or abuse
- ingestion of non-domestic meats
- immunocompromised host
- use of inhaled corticosteroids
- lack of immunisation or vaccine failure
Diagnostic investigations
1st investigations to order
- rapid antigen test for group A Streptococcus (GAS)
- nucleic acid amplification (via polymerase chain reaction) for group A Streptococcus (GAS)
Investigations to consider
- culture of throat swab for group A Streptococcus (GAS)
- culture or PCR of throat swab for gonococcus or chlamydia
- serum monospot for Epstein-Barr virus infection
Treatment algorithm
ACUTE
Contributors
Authors
Jeffrey R. Donowitz, MD
Pediatrician
Pediatric Infectious Diseases
University of Virginia
Charlottesville
VA
Disclosures
JRD declares that he has no competing interests.
Acknowledgements
Dr Jeffrey R. Donowitz would like to gratefully acknowledge Dr William A. Petri, Jr, a previous contributor to this topic.
Disclosures
WAP declares that he has no competing interests.
Peer reviewers
Richard Roberts, MD, JD, FAAFP, FCLM
Professor of Family Medicine
University of Wisconsin School of Medicine and Public Health
Madison
WI
Disclosures
RR declares that he has no competing interests.
Remco de Bree, MD, PhD
Otolaryngologist
Head and Neck Surgeon
VU University Medical Center
Amsterdam
The Netherlands
Disclosures
RdB declares that he has no competing interests.
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