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Last reviewed: 10 Mar 2025
Last updated: 18 Jun 2024

Summary

Your Organisational Guidance

ebpracticenet urges you to prioritise the following organisational guidance:

Acute KeelpijnPublished by: Werkgroep Ontwikkeling Richtlijnen Eerste Lijn (Worel)Last published: 2017Mal de gorge aiguPublished by: Groupe de Travail Développement de recommmandations de première ligneLast published: 2017

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • child or adolescent age
  • winter or spring season (in bacterial pharyngitis)
  • summer/autumn season (in enteroviral pharyngitis)
  • rhinorrhoea, nasal congestion, hoarseness, oral ulcers, and cough (in viral infection)
  • sore throat
  • pharyngeal exudate
  • cervical adenopathy
  • fever
  • headache
  • nausea, vomiting, and abdominal pain
  • conjunctivitis
  • maculopapular rash (in measles)
  • Koplik spots (in measles)
  • scarlatiniform rash (in group A Streptococcus [GAS] pharyngitis)

Other diagnostic factors

  • sexual activity or abuse (in HIV, gonorrhoeal, or chlamydial infection)
  • treatment failure of penicillin
  • pharyngeal ulceration (in tularaemia)
  • pharyngeal grey membrane (in diphtheria)

Risk factors

  • nasal colonisation with group A Streptococcus (GAS)
  • GAS-infected contact
  • sexual activity or abuse
  • ingestion of non-domestic meats
  • immunocompromised host
  • use of inhaled corticosteroids
  • lack of immunisation or vaccine failure

Diagnostic investigations

1st investigations to order

  • rapid antigen test for group A Streptococcus (GAS)
  • nucleic acid amplification (via polymerase chain reaction) for group A Streptococcus (GAS)

Investigations to consider

  • culture of throat swab for group A Streptococcus (GAS)
  • culture or PCR of throat swab for gonococcus or chlamydia
  • serum monospot for Epstein-Barr virus infection

Treatment algorithm

Contributors

Authors

Jeffrey R. Donowitz, MD

Pediatrician

Pediatric Infectious Diseases

University of Virginia

Charlottesville

VA

Disclosures

JRD declares that he has no competing interests.

Acknowledgements

Dr Jeffrey R. Donowitz would like to gratefully acknowledge Dr William A. Petri, Jr, a previous contributor to this topic.

Disclosures

WAP declares that he has no competing interests.

Peer reviewers

Richard Roberts, MD, JD, FAAFP, FCLM

Professor of Family Medicine

University of Wisconsin School of Medicine and Public Health

Madison

WI

Disclosures

RR declares that he has no competing interests.

Remco de Bree, MD, PhD

Otolaryngologist

Head and Neck Surgeon

VU University Medical Center

Amsterdam

The Netherlands

Disclosures

RdB declares that he has no competing interests.

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