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Last reviewed: 17 Mar 2025
Last updated: 11 Mar 2025

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • hoarseness
  • dysphagia
  • sore throat
  • odynophagia
  • cough
  • hyperaemia of the oropharynx
  • history of heavy vocal use
  • gastro-oesophageal reflux
  • oropharyngeal white-grey exudates

Other diagnostic factors

  • rhinitis
  • fatigue and malaise
  • fever
  • enlarged tonsils
  • enlarged, tender anterior cervical lymph nodes
  • post-nasal drip
  • dyspnoea
  • weight loss
  • tonsillopharyngeal exudate
  • acute respiratory distress
  • toxic appearance
  • drooling
  • stridor

Risk factors

  • recent history of upper respiratory infection
  • incomplete or absent Haemophilus influenzae type B (Hib) vaccination
  • incomplete or absent diphtheria vaccination
  • contact with infected individual
  • travel to area where diphtheria or tuberculosis are endemic
  • HIV or other immunocompromise
  • use of inhaled corticosteroids or prolonged courses of antibiotics
  • heavy vocal use
  • tobacco use

Diagnostic investigations

Investigations to consider

  • biopsy
  • oropharyngeal cultures
  • nasal swab for culture
  • serum immunoprecipitation or polymerase chain reaction for diphtheria
  • full blood count
  • rapid antigen detection test
  • chest x-ray
  • sputum cultures
  • videostroboscopy

Treatment algorithm

Contributors

Authors

Vaninder Kaur Dhillon, MD

Assistant Professor

Johns Hopkins University

Otolaryngology-Head and Neck Surgery

Divisions of Laryngology and Endocrine Head and Neck Surgery

Bethesda

MD

Disclosures

VKD declares that she has no competing interests.

Acknowledgements

Dr Vaninder Kaur Dhillon would like to gratefully acknowledge Dr Chad W. Whited, Dr Seth H. Dailey and Dr Ozlem E. Tulunay-Ugur, the previous contributors to this topic. CWW, SHD and OETU declare that they have no competing interests.

Peer reviewers

Michael Johns, MD

Director

Assistant Professor

Emory University

Atlanta

GA

Disclosures

MJ declares that he has no competing interests.

James Suen, MD

Chair; Professor

University of Arkansas for Medical Sciences

Department of Otolaryngology - Head and Neck Surgery

Little Rock

AR

Disclosures

JS declares that he has no competing interests.

Remco de Bree, MD, PhD

Otolaryngologist

Head and Neck Surgeon

VU University Medical Center

Amsterdam

The Netherlands

Disclosures

RdB declares that he has no competing interests.

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