Obsessive-compulsive disorder

It is recommended that the Yale-Brown Obsessive-Compulsive Scale be repeated periodically (approximately every 6 months) in order to track treatment progress. Patients on second-generation neuroleptics should undergo metabolic monitoring.[165]Sernyak MJ. Implementation of monitoring and management guidelines for second-generation antipsychotics. J Clin Psychiatry. 2007;68:14-18. http://www.ncbi.nlm.nih.gov/pubmed/17539695?tool=bestpractice.com

Patients on antipsychotic drugs or clomipramine should be evaluated periodically by ECG screening for potential cardiac toxicity (at baseline and approximately every 6 months once maintenance dose is determined). Patients on clomipramine should have serum levels of clomipramine and desmethylclomipramine evaluated periodically as well (at baseline, with dosage increases, and approximately every 6 months once maintenance dose is determined).