Acute monitoring of blood glucose
Re-check the patient’s blood glucose after 10-15 minutes and repeat administration of intravenous or oral glucose until the hypoglycaemia has resolved (i.e., repeat administration if blood glucose remains <3.9 mmol/L [<70 mg/dL]).[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[106]Desimone ME, Weinstock RS. Hypoglycemia. In: Feingold KR, Anawalt B, Boyce A, et al., eds. Endotext. South Dartmouth, MA: MDText.com, Inc.; 2000 (updated May 2018).
https://www.ncbi.nlm.nih.gov/books/NBK279137
Long-term monitoring
Clinicians should assess any episodes of hypoglycaemia (both confirmed and suspected) and the possibility of impaired awareness of hypoglycaemia at each patient visit.[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
For more information on impaired awareness of hypoglycaemia, see Complications.
Monitoring of blood glucose is key for all patients with type 1 diabetes (and, in practice, any child being treated with insulin).[2]Seaquist ER, Anderson J, Childs B, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care. 2013 May;36(5):1384-95.
https://diabetesjournals.org/care/article/36/5/1384/29546/Hypoglycemia-and-Diabetes-A-Report-of-a-Workgroup
http://www.ncbi.nlm.nih.gov/pubmed/23589542?tool=bestpractice.com
[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
In particular, patients should monitor their blood glucose at times of particular risk of hypoglycaemia, such as during sleep or prior to exercise.[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
In children, monitoring of blood glucose overnight is particularly important if they have additional risk factors for nocturnal hypoglycaemia, such as younger age, lower HbA1c levels, and previous hypoglycaemia associated with exercise.[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
[124]Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. Prolonged nocturnal hypoglycemia is common during 12 months of continuous glucose monitoring in children and adults with type 1 diabetes. Diabetes Care. 2010 May;33(5):1004-8.
https://diabetesjournals.org/care/article/33/5/1004/26909/Prolonged-Nocturnal-Hypoglycemia-Is-Common-During
http://www.ncbi.nlm.nih.gov/pubmed/20200306?tool=bestpractice.com
A child or young person having recurrent episodes of hypoglycaemia should have increased input from their diabetes team.[38]National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].
https://www.nice.org.uk/guidance/ng18
Blood glucose monitoring is recommended in adult patients with type 2 diabetes who:[77]National Institute for Health and Care Excellence. Type 2 diabetes in adults: management. Jun 2022 [internet publication].
https://www.nice.org.uk/guidance/ng28
Have had prior hypoglycaemic episodes
Are taking insulin[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[76]Grunberger G, Sherr J, Allende M, et al. American Association of Clinical Endocrinology clinical practice guideline: the use of advanced technology in the management of persons with diabetes mellitus. Endocr Pract. 2021 Jun;27(6):505-37.
https://www.endocrinepractice.org/article/S1530-891X(21)00165-8/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/34116789?tool=bestpractice.com
Drive or operate machinery and use oral medications that increase the patient's risk of hypoglycaemia
Are pregnant, or planning to become pregnant.
Hypoglycaemia risk should be considered when setting HbA1c targets for patients with type 2 diabetes, as targets may need to be relaxed if they have experienced severe hypoglycaemic episodes or have reduced hypoglycaemic awareness.[73]Samson SL, Vellanki P, Blonde L, et al. American Association of Clinical Endocrinology consensus statement: comprehensive type 2 diabetes management algorithm - 2023 update. Endocr Pract. 2023 May;29(5):305-40.
https://www.endocrinepractice.org/article/S1530-891X(23)00034-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/37150579?tool=bestpractice.com
Continuous glucose monitoring (CGM) is the preferred technique to monitor blood glucose for most patients.[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
[17]McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.
https://academic.oup.com/jcem/article/108/3/529/6880627
http://www.ncbi.nlm.nih.gov/pubmed/36477488?tool=bestpractice.com
[38]National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].
https://www.nice.org.uk/guidance/ng18
[59]National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].
https://www.nice.org.uk/guidance/ng17
[76]Grunberger G, Sherr J, Allende M, et al. American Association of Clinical Endocrinology clinical practice guideline: the use of advanced technology in the management of persons with diabetes mellitus. Endocr Pract. 2021 Jun;27(6):505-37.
https://www.endocrinepractice.org/article/S1530-891X(21)00165-8/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/34116789?tool=bestpractice.com
Patients using CGM and their family or carers should have ongoing education and support in using their device and be encouraged to use it continuously.[38]National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].
https://www.nice.org.uk/guidance/ng18
Self-monitoring of blood glucose (SMBG) is an alternative.[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
[38]National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].
https://www.nice.org.uk/guidance/ng18
[59]National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].
https://www.nice.org.uk/guidance/ng17
[125]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 7. Diabetes technology: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S111-27.
https://diabetesjournals.org/care/article/46/Supplement_1/S111/148041/7-Diabetes-Technology-Standards-of-Care-in
http://www.ncbi.nlm.nih.gov/pubmed/36507635?tool=bestpractice.com
CGM has become increasingly available and is the preferred method of monitoring blood glucose for patients with diabetes who are being treated with insulin, particularly if they are receiving multiple daily injections of insulin or using an insulin pump.[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
[17]McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.
https://academic.oup.com/jcem/article/108/3/529/6880627
http://www.ncbi.nlm.nih.gov/pubmed/36477488?tool=bestpractice.com
[38]National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].
https://www.nice.org.uk/guidance/ng18
[73]Samson SL, Vellanki P, Blonde L, et al. American Association of Clinical Endocrinology consensus statement: comprehensive type 2 diabetes management algorithm - 2023 update. Endocr Pract. 2023 May;29(5):305-40.
https://www.endocrinepractice.org/article/S1530-891X(23)00034-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/37150579?tool=bestpractice.com
CGM is also preferred over SMBG in patients with type 2 diabetes who are at risk of or have recurrent hypoglycaemia (e.g., those taking sulfonylureas or those with impaired hypoglycaemia awareness).[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
[17]McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.
https://academic.oup.com/jcem/article/108/3/529/6880627
http://www.ncbi.nlm.nih.gov/pubmed/36477488?tool=bestpractice.com
[73]Samson SL, Vellanki P, Blonde L, et al. American Association of Clinical Endocrinology consensus statement: comprehensive type 2 diabetes management algorithm - 2023 update. Endocr Pract. 2023 May;29(5):305-40.
https://www.endocrinepractice.org/article/S1530-891X(23)00034-4/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/37150579?tool=bestpractice.com
[125]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 7. Diabetes technology: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S111-27.
https://diabetesjournals.org/care/article/46/Supplement_1/S111/148041/7-Diabetes-Technology-Standards-of-Care-in
http://www.ncbi.nlm.nih.gov/pubmed/36507635?tool=bestpractice.com
In patients treated with insulin, real-time CGM resulted in better glycaemic control and lower rates of hypoglycaemia and emergency department visits or hospitalisation for hypoglycaemia compared with SMBG.[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
[125]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 7. Diabetes technology: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S111-27.
https://diabetesjournals.org/care/article/46/Supplement_1/S111/148041/7-Diabetes-Technology-Standards-of-Care-in
http://www.ncbi.nlm.nih.gov/pubmed/36507635?tool=bestpractice.com
[126]Watanabe Y, Tokunaga K, Geraghty DE, et al. Large-scale comparative mapping of the MHC class I region of predominant haplotypes in Japanese. Immunogenetics. 1997;46(2):135-41.
http://www.ncbi.nlm.nih.gov/pubmed/9162100?tool=bestpractice.com
The American Association of Clinical Endocrinology strongly recommends CGM for all patients with diabetes treated with intensive insulin therapy, defined as three or more injections of insulin per day or the use of an insulin pump.[76]Grunberger G, Sherr J, Allende M, et al. American Association of Clinical Endocrinology clinical practice guideline: the use of advanced technology in the management of persons with diabetes mellitus. Endocr Pract. 2021 Jun;27(6):505-37.
https://www.endocrinepractice.org/article/S1530-891X(21)00165-8/fulltext
http://www.ncbi.nlm.nih.gov/pubmed/34116789?tool=bestpractice.com
In a multi-site registry of 3553 paediatric patients with type 1 diabetes, the introduction of CGM was associated with fewer patients experiencing severe hypoglycaemia over a 1-year observation period.[127]Tauschmann M, Hermann JM, Freiberg C, et al. Reduction in diabetic ketoacidosis and severe hypoglycemia in pediatric type 1 diabetes during the first year of continuous glucose monitoring: a multicenter analysis of 3,553 subjects from the DPV Registry. Diabetes Care. 2020 Mar;43(3):e40-2.
https://diabetesjournals.org/care/article/43/3/e40/35632/Reduction-in-Diabetic-Ketoacidosis-and-Severe
http://www.ncbi.nlm.nih.gov/pubmed/31969340?tool=bestpractice.com
Be aware, however, that inpatient CGM use is not currently approved by the US Food and Drug Administration (FDA), but does currently have enforcement discretion (i.e., for patients who are at high risk of hypoglycaemia).[17]McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.
https://academic.oup.com/jcem/article/108/3/529/6880627
http://www.ncbi.nlm.nih.gov/pubmed/36477488?tool=bestpractice.com
Even though CGM is the preferred option for most patients, SMBG may still be necessary to validate or confirm blood glucose levels obtained from CGM (such as during exercise, when CGM readings become less accurate).[17]McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.
https://academic.oup.com/jcem/article/108/3/529/6880627
http://www.ncbi.nlm.nih.gov/pubmed/36477488?tool=bestpractice.com
[37]Adolfsson P, Taplin CE, Zaharieva DP, et al. ISPAD clinical practice consensus guidelines 2022: exercise in children and adolescents with diabetes. Pediatr Diabetes. 2022;23(8):1341-72.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13452
[38]National Institute for Health and Care Excellence. Diabetes (type 1 and type 2) in children and young people: diagnosis and management. May 2023 [internet publication].
https://www.nice.org.uk/guidance/ng18
[59]National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management. Aug 2022 [internet publication].
https://www.nice.org.uk/guidance/ng17
For more information on general monitoring of diabetes, see the following topics: Type 1 diabetes, Type 2 diabetes in adults, and Type 2 diabetes in children.