Test
Urgently carry out a blood glucose level for any patient with suspected diabetic hypoglycaemia, which is a finger stick test that is performed at the bedside or in an outpatient setting. In practice, if finger stick testing is not available, start treatment if the patient has typical symptoms and signs of hypoglycaemia.
Confirm diabetic hypoglycaemia if blood glucose is <3.9 mmol/L (<70 mg/dL).[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
In clinical practice, this is used as the clinical alert or threshold value that should prompt treatment for hypoglycaemia in diabetes to prevent further fall in blood glucose.[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
[2]Seaquist ER, Anderson J, Childs B, et al. Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care. 2013 May;36(5):1384-95.
https://diabetesjournals.org/care/article/36/5/1384/29546/Hypoglycemia-and-Diabetes-A-Report-of-a-Workgroup
http://www.ncbi.nlm.nih.gov/pubmed/23589542?tool=bestpractice.com
[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
However, be aware that hypoglycaemia is defined as any fall in blood glucose that exposes a patient to potential harm as there is no single numerical definition of hypoglycaemia for all patients and situations.[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
Suspect nocturnal hypoglycaemia if the patient's pre-breakfast blood glucose is low.[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
Take appropriate action according to the severity of hypoglycaemia. Start immediate treatment for any patient with level 2 or 3 hypoglycaemia.[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
Severity of diabetic hypoglycaemia is classified as follows:[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
[4]Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2021 Dec;64(12):2609-52.
https://link.springer.com/article/10.1007/s00125-021-05568-3
http://www.ncbi.nlm.nih.gov/pubmed/34590174?tool=bestpractice.com
[17]McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.
https://academic.oup.com/jcem/article/108/3/529/6880627
http://www.ncbi.nlm.nih.gov/pubmed/36477488?tool=bestpractice.com
Level 3 (severe): no defined blood glucose. Severe event characterised by altered mental and/or physical status requiring assistance for treatment of hypoglycaemia.
Level 2 (clinically significant; also referred to as clinically important or serious): blood glucose <3.0 mmol/L (<54 mg/dL). This is usually the threshold at which neuroglycopenic symptoms occur.[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
In addition, be aware that a patient with impaired awareness of hypoglycaemia may not present with typical signs and symptoms of hypoglycaemia.[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
[3]ElSayed NA, Aleppo G, Aroda VR, et al; American Diabetes Association. 6. Glycemic targets: standards of care in diabetes - 2023. Diabetes Care. 2023 Jan 1;46(1 suppl):S97-110.
https://diabetesjournals.org/care/article/46/Supplement_1/S97/148053/6-Glycemic-Targets-Standards-of-Care-in-Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/36507646?tool=bestpractice.com
Level 1 (alert value): blood glucose <3.9 mmol/L (<70 mg/dL) and ≥3.0 mmol/L (≥54 mg/dL). Advise the patient that this value should alert them to the possibility of developing level 2 hypoglycaemia and can be used as a threshold to take appropriate actions to prevent this (e.g., carbohydrate ingestion, adjusting medication).[1]Abraham MB, Karges B, Dovc K, et al. ISPAD Clinical Practice Consensus Guidelines 2022: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2022 Dec;23(8):1322-40.
https://onlinelibrary.wiley.com/doi/10.1111/pedi.13443
http://www.ncbi.nlm.nih.gov/pubmed/36537534?tool=bestpractice.com
[5]Danne T, Nimri R, Battelino T, et al. International consensus on use of continuous glucose monitoring. Diabetes Care. 2017 Dec;40(12):1631-40.
https://diabetesjournals.org/care/article/40/12/1631/37000/International-Consensus-on-Use-of-Continuous
http://www.ncbi.nlm.nih.gov/pubmed/29162583?tool=bestpractice.com