Bisphosphonates (e.g., zoledronic acid) are used to reduce the incidence of skeletal-related events, including spinal cord compression, in patients with bone metastases.[26]Gralow JR, Biermann JS, Farooki A, et al. NCCN task force report: bone health in cancer care. J Natl Compr Canc Netw. 2009 Jun;7 Suppl 3:S1-32; quiz S33-5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047404
http://www.ncbi.nlm.nih.gov/pubmed/19555589?tool=bestpractice.com
[27]O'Carrigan B, Wong MH, Willson ML, et al. Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev. 2017 Oct 30;(10):CD003474.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003474.pub4/full
http://www.ncbi.nlm.nih.gov/pubmed/29082518?tool=bestpractice.com
Renal function should be monitored closely in patients taking bisphosphonates.[26]Gralow JR, Biermann JS, Farooki A, et al. NCCN task force report: bone health in cancer care. J Natl Compr Canc Netw. 2009 Jun;7 Suppl 3:S1-32; quiz S33-5.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047404
http://www.ncbi.nlm.nih.gov/pubmed/19555589?tool=bestpractice.com