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Last reviewed: 19 Mar 2025
Last updated: 24 Oct 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • pain
  • soft-tissue swelling
  • ecchymosis
  • expanding haematoma
  • impaired limb function
  • inability to bear weight
  • point tenderness
  • deformity
  • guarding
  • wound overlying site of injury
  • signs of vascular injury
  • signs of acute compartment syndrome
  • hypotension/hypovolaemic shock

Other diagnostic factors

  • altered nerve sensation
  • impaired motor function
  • bony crepitus
  • callus
  • reproduction of symptoms in stress fractures of the neck or shaft of the femur

Risk factors

  • direct trauma
  • indirect trauma
  • osteoporosis (insufficiency fractures)
  • chronic renal failure
  • diabetes mellitus
  • bone tumour (pathological fractures)
  • age >70 years
  • age <30 years
  • male sex (acute fractures)
  • female sex (stress and insufficiency fractures)
  • prolonged corticosteroid use (insufficiency fractures)
  • low body mass index (insufficiency fractures)
  • history of recent fall
  • prior fracture (insufficiency fractures)
  • seizures (proximal humerus fracture)
  • long-term bisphosphonate use

Diagnostic investigations

1st investigations to order

  • x-ray limb
  • FBC, blood typing, and cross-matching (major trauma)

Investigations to consider

  • whole body CT (adults)
  • non-contrast CT of fracture
  • MRI limb
  • compartment pressure testing
  • ultrasound duplex scanning
  • angiography
  • dual-energy x-ray absorptiometry bone density scan
  • triple-phase bone scan

Treatment algorithm

Contributors

Expert advisers

Michael Barrett, MBChB, FRCS (Tr & Orth), PG Cert Med Ed

Consultant Trauma and Orthopaedic Surgeon

Cambridge University Hospitals NHS Foundation Trust

Cambridge

UK

Disclosures

MB is a director of Orthohub.xyz, an online education platform for orthopaedic surgeons. Orthohub.xyz receives sponsorship from the healthcare industry.

Acknowledgements

BMJ Best Practice would like to gratefully acknowledge the previous expert contributor, whose work has been retained in parts of the content:

Philip H. Cohen MD

Attending Physician

Rutgers University Health Services

Clinical Assistant Professor of Internal Medicine and Family Medicine

Rutgers Robert Wood Johnson Medical School

Piscataway

NJ

Disclosures

PHC has given lectures for MCE Conferences, a medical education company, and received a stipend/free hotel room during the conference. MCE Conferences accepts no funding from pharmaceutical companies or other outside agencies, and PHC declares that the lectures have no impact on the topic.

Peer reviewers

Alex Trompeter, BSc (Hons.) MBBS FRCS (Tr+Orth)

Orthopaedic Trauma/Limb Reconstruction Surgeon

St George's University Hospitals NHS Foundation Trust

London Reader in Orthopaedic Surgery

St George's, University of London

Training Programme Director

South West London Orthopaedic Rotation

London

UK

Disclosures

AT declares that he has no competing interests.

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