Most adult deaths occur in patients whose concentrations exceed 700 mg/L (5.1 mmol/L).[2]National Poisons Information Service. TOXBASE®: salicylic acids and salicylates (salicylates). May 2019 [internet publication].
https://www.toxbase.org/Poisons-Index-A-Z/S-Products/Salicylates
[9]Chapman BJ, Proudfoot AT. Adult salicylate poisoning: deaths and outcome in patients with high plasma salicylate concentrations. Q J Med. 1989 Aug;72(268):699-707.
http://www.ncbi.nlm.nih.gov/pubmed/2602553?tool=bestpractice.com
Patients are more likely to die if they are aged over 70 years, or if they develop coma, convulsions, confusion, agitation, hyperpyrexia, pulmonary oedema, or metabolic acidosis.[2]National Poisons Information Service. TOXBASE®: salicylic acids and salicylates (salicylates). May 2019 [internet publication].
https://www.toxbase.org/Poisons-Index-A-Z/S-Products/Salicylates
[9]Chapman BJ, Proudfoot AT. Adult salicylate poisoning: deaths and outcome in patients with high plasma salicylate concentrations. Q J Med. 1989 Aug;72(268):699-707.
http://www.ncbi.nlm.nih.gov/pubmed/2602553?tool=bestpractice.com
Substantial clinical signs and symptoms, particularly neurological signs and non-cardiogenic pulmonary oedema, can be present with lower levels of salicylate, particularly in cases of chronic ingestions. Therefore, salicylate level alone is not a reliable predictor of outcome.
Non-fatal salicylate poisoning is associated with a full recovery.[7]Dargan PI, Wallace CI, Jones AL. An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose. Emerg Med J. 2002 May;19(3):206-9.
https://emj.bmj.com/content/19/3/206.long
http://www.ncbi.nlm.nih.gov/pubmed/11971828?tool=bestpractice.com