Approximately 1.4 million patients are attended annually in hospital following a head injury in England and Wales. About 68% of those admitted (n=15,080) have a mild traumatic brain injury (TBI) on admission.[8]Lawrence T, Helmy A, Bouamra O, et al. Traumatic brain injury in England and Wales: prospective audit of epidemiology, complications and standardised mortality. BMJ Open. 2016 Nov 24;6(11):e012197.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168492
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Mild TBI is estimated to affect 55.9 million people globally each year.[9]Dewan MC, Rattani A, Gupta S, et al. Estimating the global incidence of traumatic brain injury. J Neurosurg. 2018 Apr 27;130(4):1080-97.
https://thejns.org/view/journals/j-neurosurg/130/4/article-p1080.xml
http://www.ncbi.nlm.nih.gov/pubmed/29701556?tool=bestpractice.com
Mild TBI, which represents approximately 90% of all TBIs, increasingly affects ageing populations who experience falls, and increasing incidence may also reflect rising numbers of road traffic collisions in low- and middle-income countries and widespread concerns regarding long-term effects of sports-related concussion.[10]Woodrow RE, Winzeck S, Luppi AI, et al. Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury. Brain. 2023 Aug 1;146(8):3484-99.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393415
http://www.ncbi.nlm.nih.gov/pubmed/36811945?tool=bestpractice.com
[11]Maas AIR, Menon DK, Adelson PD, et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. Lancet Neurol. 2017 Dec;16(12):987-1048.
https://orbi.uliege.be/handle/2268/249925
http://www.ncbi.nlm.nih.gov/pubmed/29122524?tool=bestpractice.com
Young men represent nearly two-thirds of the cases seen each year worldwide.[12]Radanov BP, Dvorak J, Valach L. Cognitive deficits in patients after soft tissue injury of the cervical spine. Spine (Phila Pa 1976). 1992 Feb;17(2):127-31.
http://www.ncbi.nlm.nih.gov/pubmed/1553581?tool=bestpractice.com
[13]McCrea MA. Mild traumatic brain injury and postconcussion syndrome: the new evidence base for diagnosis and treatment. Oxford Workshop Series. New York, NY: Oxford University Press; 2008. Concussion incidence rates appear to be significantly higher in women than in men for a number of team sports, including soccer, ice hockey, and basketball.[12]Radanov BP, Dvorak J, Valach L. Cognitive deficits in patients after soft tissue injury of the cervical spine. Spine (Phila Pa 1976). 1992 Feb;17(2):127-31.
http://www.ncbi.nlm.nih.gov/pubmed/1553581?tool=bestpractice.com
[13]McCrea MA. Mild traumatic brain injury and postconcussion syndrome: the new evidence base for diagnosis and treatment. Oxford Workshop Series. New York, NY: Oxford University Press; 2008.[14]Bretzin AC, Covassin T, Wiebe DJ, et al. Association of sex with adolescent soccer concussion incidence and characteristics. JAMA Netw Open. 2021 Apr 1;4(4):e218191.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080231
http://www.ncbi.nlm.nih.gov/pubmed/33904911?tool=bestpractice.com
Women typically report more complex symptomatology and slower recovery.[2]Maas AIR, Menon DK, Manley GT, et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 2022 Nov;21(11):1004-60.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10427240
http://www.ncbi.nlm.nih.gov/pubmed/36183712?tool=bestpractice.com
[15]Farace E, Alves WM. Do women fare worse? A metaanalysis of gender differences in outcome after traumatic brain injury. Neurosurg Focus. 2000;8(1):e6.
http://www.ncbi.nlm.nih.gov/pubmed/16924776?tool=bestpractice.com
[16]Colvin AC, Mullen J, Lovell MR, et al. The role of concussion history and gender in recovery from soccer-related concussion. Am J Sports Med. 2009 Sep;37(9):1699-704.
http://www.ncbi.nlm.nih.gov/pubmed/19460813?tool=bestpractice.com
[17]Bazarian JJ, Blyth B, Mookerjee S, et al. Sex differences in outcome after mild traumatic brain injury. J Neurotrauma. 2010 Mar;27(3):527-39.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867588
http://www.ncbi.nlm.nih.gov/pubmed/19938945?tool=bestpractice.com