Evidence
This page contains a snapshot of featured content which highlights evidence addressing key clinical questions including areas of uncertainty. Please see the main topic reference list for details of all sources underpinning this topic.
BMJ Best Practice evidence tables
Evidence tables provide easily navigated layers of evidence in the context of specific clinical questions, using GRADE and a BMJ Best Practice Effectiveness rating. Follow the links at the bottom of the table, which go to the related evidence score in the main topic text, providing additional context for the clinical question. Find out more about our evidence tables.
This table is a summary of the analysis reported in a Cochrane Clinical Answer that focuses on the above important clinical question.
Confidence in the evidence is very low or low where GRADE has been performed and there may be no difference in effectiveness between the intervention and comparison for key outcomes. However, this is uncertain and new evidence could change this in the future.
Population: Pregnant women with culture-confirmed asymptomatic bacteriuria
Intervention: Single higher dose oral antibiotic ᵃ
Comparison: Lower dose oral antibiotic (4-7 day course) ᵃ
| Outcome | Effectiveness (BMJ rating)? | Confidence in evidence (GRADE)? |
|---|---|---|
No cure (time frame not reported) | No statistically significant difference | Very Low |
Recurrent asymptomatic bacteriuria (time frame not reported) | No statistically significant difference | Very Low |
Pyelonephritis (time frame not reported) | No statistically significant difference | Very Low |
Preterm delivery (time frame not reported) | No statistically significant difference | Moderate |
Low birthweight (time frame not reported) | Favours comparison | High |
Adverse effects (time frame not reported) | Occurs more commonly with lower dose compared with higher dose (favours intervention) | Low |
Note ᵃ This evidence table summarises the findings for the comparison of a single higher-dose antibiotic versus short-course (4-7 day) antibiotic, which is the main comparison as stated in the Cochrane review Summary of Findings table. They did not find any RCTs on the other comparisons of interest (single higher-dose oral antibiotic versus 14-day lower-dose oral antibiotic; single higher-dose oral antibiotic versus continuous [until delivery] lower dose oral antibiotic). See the full Cochrane Clinical Answer (CCA) for more information.
This evidence table is related to the following section/s:
Cochrane Clinical Answers
Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.
- How does single‐dose treatment compare with longer‐course antibiotics for asymptomatic bacteriuria during pregnancy?
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