History and exam

Key diagnostic factors

common

acute, severe flank pain

Classical renal colic is described as severe, acute flank pain that radiates to the ipsilateral groin. However, some patients may have no radiation and some stones are asymptomatic.

Other diagnostic factors

common

risk factors

Take a history covering key risk factors for stone formation, including: dehydration, diet (particularly high salt intake), white ancestry, male sex, obesity, and crystalluria.

previous episodes of nephrolithiasis

More than 40% of patients with renal stones will have another episode within 10 years.[63][64]

nausea and vomiting

Commonly associated with acute episode.

urinary frequency/urgency

As stones pass and get lodged in the distal ureter or intramural tunnel, this can lead to bladder irritation manifested as urinary frequency or urgency.

haematuria

Microscopic haematuria is present on urinalysis up to 84% to 90% of cases of nephrolithiasis.[49][50] Rarely, macroscopic haematuria can be present.

testicular pain

As stones pass through the ureter, flank pain can radiate towards the groin and testicle, leading to testicular pain.

obesity

Increased incidence of renal stones is correlated with increased body mass index (BMI) in both sexes.[12]

uncommon

family history of nephrolithiasis

May be positive for nephrolithiasis in first-degree relatives. If so, this could suggest an underlying metabolic abnormality.

precipitant medications

Potential medications that can play a role in formation of renal stones include antacids, carbonic anhydrase inhibitors, sodium- and calcium-containing medications, vitamins C and D, and protease inhibitors.[35]

groin pain

As stones pass through the ureter, flank pain can radiate towards the groin.

fever

If also associated with urinary obstruction, urgent decompression is needed.

tachycardia

May indicate sepsis.

hypotension

May indicate sepsis.

costovertebral angle and ipsilateral flank tenderness

May be pronounced in acute renal colic.

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