Nephrolithiasis is a lifelong disease process. The rate of recurrence of nephrolithiasis is 50% at 5 years.[2]Khan SR, Pearle MS, Robertson WG, et al. Kidney stones. Nat Rev Dis Primers. 2016 Feb 25;2:16008.
http://www.ncbi.nlm.nih.gov/pubmed/27188687?tool=bestpractice.com
Risk factors for stone recurrence include younger age, higher body mass index, and family history of kidney stones. The patients at highest risk for recurrence are frequently those who do not adhere to medical therapy and dietary/lifestyle modifications, or where underlying metabolic abnormalities exist. Residual stone fragments from surgery will usually spontaneously pass as long as their size is <4 mm, though there is no significant association between the size of residual stones and subsequent disease progression.[122]Brain E, Geraghty RM, Lovegrove CE, et al. Natural history of post-treatment kidney stone fragments: a systematic review and meta-analysis. J Urol. 2021 Sep;206(3):526-38.
https://www.doi.org/10.1097/JU.0000000000001836
http://www.ncbi.nlm.nih.gov/pubmed/33904756?tool=bestpractice.com
[123]Lovegrove CE, Geraghty RM, Yang B, et al. Natural history of small asymptomatic kidney and residual stones over a long-term follow-up: systematic review over 25 years. BJU Int. 2022 Apr;129(4):442-56.
https://www.doi.org/10.1111/bju.15522
http://www.ncbi.nlm.nih.gov/pubmed/34157218?tool=bestpractice.com
The Return of Kidney Stones (ROKS) nomogram can be used to help to predict the risk of a second kidney stone.[124]Rule AD, Lieske JC, Li X, et al. The ROKS nomogram for predicting a second symptomatic stone episode. J Am Soc Nephrol. 2014 Dec;25(12):2878-86.
http://www.ncbi.nlm.nih.gov/pubmed/25104803?tool=bestpractice.com