Investigations

1st investigations to order

no first test

Test
Result
Test

Result

diagnosis is usually clinical

Investigations to consider

MRI

Test
Result
Test

Not necessary for clinical diagnosis of classical trigeminal neuralgia. Necessary if secondary trigeminal neuralgia is suspected. Some guidelines recommend that magnetic resonance imaging (MRI) should be performed for all patients; no clinical characteristic can reliably exclude secondary TN.[20][21][22]​​​

Should always be performed prior to surgery or other procedural therapeutic maneuvers to exclude secondary causes. MRI of the head without and with IV contrast or MRI of the orbits, face and neck without and with IV contrast are appropriate for the initial imaging of patients with trigeminal neuralgia; they may be used as equivalent alternatives or as complementary procedures.[21] 3D heavily T2-weighted MRI sequences, magnetic resonance angiography (MRA), and a combination of the two can be used to determine the anatomy of the vascular loops that may be compressing the trigeminal nerve.[21][23]​​​

Result

may demonstrate presence of abnormal vessel loop in association with the trigeminal nerve, presence of other pathologies (e.g., tumour, infarct, multiple sclerosis plaque)

trigeminal reflex testing

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Result
Test

Used for distinguishing secondary TN from classical or idiopathic TN if MRI is contraindicated or unavailable.[20][22]​​​​

Result

early blink reflex or early masseter inhibitory reflex in TN

intra-oral x-ray

Test
Result
Test

Only required if dental cause of pain suspected. May demonstrate dental caries, dental fracture, osteomyelitis.

Result

no dental cause of pain demonstrated

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