Cochrane Clinical Answers

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Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically focused entry point to rigorous research from Cochrane systematic reviews. They are designed to be actionable and to inform decision making at the point of care and have been added to relevant sections of the main Best Practice text.

  • What are the effects of exercise for people with hip and/or knee osteoarthritis?
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  • Is there randomized controlled trial evidence to support the use of exercise in people with osteoarthritis of the knee?
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  • In people with osteoarthritis of the hip, what are the benefits and harms of exercise?
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  • How do braces and orthoses affect outcomes in people being treated for osteoarthritis of the knee?
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  • How does chondroitin affect outcomes in people with osteoarthritis?
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  • In adults with chronic musculoskeletal pain, is there randomized controlled trial evidence to support the use of topical NSAIDs?
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  • How does tapentadol affect outcomes in adults with chronic musculoskeletal pain?
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  • Do misoprostol, H2-receptor antagonists, or proton pump inhibitors used for at least 12 weeks prevent upper gastrointestinal ulcers in patients requiring chronic NSAID use?
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