Disseminated intravascular coagulation

Recombinant human soluble thrombomodulin (ART-123)

Thrombomodulin is a thrombin receptor on the endothelial cell surface. Recombinant human soluble thrombomodulin (ART-123) is active, extracellular domains of thrombomodulin. It acts by reducing thrombin-mediated clotting and enhancing protein C activation at the site of clotting. The agent also has anti-inflammatory properties. Randomised controlled trials suggest that, in patients with sepsis-associated disseminated intravascular coagulation (DIC), recombinant human thrombomodulin facilitates DIC recovery and, in combination with antithrombin, may improve platelet counts and D-dimer levels.[18]Hagiwara A, Tanaka N, Uemura T, et al. Can recombinant human thrombomodulin increase survival among patients with severe septic-induced disseminated intravascular coagulation: a single-centre, open-label, randomised controlled trial. BMJ Open. 2016 Dec 30;6(12):e012850. https://bmjopen.bmj.com/content/6/12/e012850.long http://www.ncbi.nlm.nih.gov/pubmed/28039291?tool=bestpractice.com [19]Yasuda N, Goto K, Ohchi Y, et al. The efficacy and safety of antithrombin and recombinant human thrombomodulin combination therapy in patients with severe sepsis and disseminated intravascular coagulation. J Crit Care. 2016 Dec;36:29-34. http://www.ncbi.nlm.nih.gov/pubmed/27546744?tool=bestpractice.com