Secondary prevention
Most complications can be prevented by meticulous management of oral calcium and vitamin D therapy to ensure that serum calcium and phosphate levels remain in the normal range. Adequate fluid intake is also important to help prevent nephrolithiasis.
If a patient with pseudohypoparathyroidism would like to conceive, preimplantation genetic diagnosis (PGD) should be considered to decrease and potentially eliminate the transmission of GNAS mutation to the fetus. PGD allows the selection of embryos without GNAS mutations for implantation.[57]
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