Epidemiology

IgAV can occur in patients of any age; however, it occurs predominantly between the ages of 2 and 10 years. Peak incidence is between 4 and 7 years.[11]

In North America, the annual incidence of IgAV in children is around 13.5 cases per 100,000 population.[1][12]​​ In the UK, routinely collected primary care data indicate that the incidence of childhood-onset IgAV is 27.22 per 100,000 person-years.[13] 

People of white and Asian ethnicity have the highest incidence, and people of black ethnicity the lowest.[1][12]​ Males are slightly more often affected than females by a ratio of up to 2:1.[12]

IgAV can follow an upper respiratory tract infection, and as a result occurs most frequently in the autumn, winter, and early spring.​[14][15]​​​ During childhood, as onset age increases, patients have arthralgia/arthritis less frequently, but are more prone to renal involvement.[16]

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