Monitoring
Blood cultures should be obtained every 1 to 2 days to confirm that negative status has been achieved. If blood cultures remain positive, rather than assuming treatment change is indicated or that resistance has developed, attention should be paid to ensure that all intravascular catheters have been removed, as well as searching for metastatic foci, such as abscesses. Persistently positive cultures mandates excluding endovascular infections, including Candida endocarditis. Antifungal susceptibility testing, primarily to azoles, is recommended for all bloodstream isolates.[22] This is particularly relevant for C glabrata, C parapsilosis and C auris , which have increasing rates of resistance to azoles and variable rates of resistance to echinocandins.[3][6][46][66]
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