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Last reviewed: 18 Mar 2025
Last updated: 21 May 2024

Summary

Definition

History and exam

Key diagnostic factors

  • history of jet travel across at least 2 time zones
  • difficulty initiating or maintaining sleep
  • reduction of total sleep time
  • daytime sleepiness
  • reduced daytime alertness

Other diagnostic factors

  • nausea, abdominal distension, constipation
  • general malaise
  • muscle cramps

Risk factors

  • multiple time zones crossed and rapidity of travel
  • sleep deprivation
  • individual susceptibility to time zone shifts
  • excessive alcohol or caffeine consumption
  • stress

Diagnostic investigations

Treatment algorithm

Contributors

Authors

Ashish Adlakha, MD

Assistant Clinical Professor

Neurology and Sleep Medicine

UConn School of Medicine VA

Connecticut Healthcare

West Haven

CT

Disclosures

AA declares that he has no competing interests.

Acknowledgements

Dr Ashish Adlakha would like to gratefully acknowledge Dr Sudhansu Chokroverty, a previous contributor to this topic.

Disclosures

SC declares that he has no competing interests.

Peer reviewers

David N. Neubauer, MD

Associate Director

Johns Hopkins Sleep Disorders Center

Baltimore

MD

Disclosures

DNN has received consulting fees and honoraria for speaking programs from Sanofi-Aventis and Takeda Pharmaceuticals. These companies manufacture medications mentioned in this topic.

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