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Last reviewed: 16 Mar 2025
Last updated: 22 Jun 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • corona phlebectatica (malleolar flare or ankle flare)
  • ankle swelling
  • hyperpigmentation (brawny oedema)
  • lipodermatosclerosis
  • atrophie blanche
  • leg ulcers

Other diagnostic factors

  • leg fatigue, aching, and/or discomfort
  • heavy legs
  • leg cramps
  • telangiectasias
  • reticular veins
  • dilated tortuous veins
  • dry and scaly skin
  • skin burning and itching
  • unilateral leg swelling

Risk factors

  • increasing age
  • family history
  • smoking
  • deep vein thrombosis
  • orthostatic occupation
  • female sex
  • obesity (waist circumference)
  • ligamentous laxity

Diagnostic investigations

Investigations to consider

  • ascending phlebography
  • CT venography
  • magnetic resonance venography
  • CT abdomen and pelvis
  • abdomen and pelvis ultrasound
  • intravascular ultrasound
  • air plethysmography

Treatment algorithm

Contributors

Authors

Joseph L. Mills Sr, MD

Professor and Chief

Division of Vascular Surgery and Endovascular Therapy

Michael E. DeBakey Department of Surgery

Baylor College of Medicine

Houston

TX

Disclosures

JLM declares that he has no competing interests.

David G. Armstrong, DPM, MD, PhD

Professor of Surgery

Director of Southwestern Academic Limb Salvage Alliance (SALSA)

Keck School of Medicine of University of Southern California (USC)

Los Angeles

CA

Disclosures

DGA declares that his work is partially supported by grants from the National Institutes of Health and the National Institute of Diabetes and Digestive and Kidney Diseases.

Peer reviewers

Anahita Dua, MD, MS, MBA, FACS

Assistant Professor of Surgery

Massachusetts General Hospital/Harvard Medical School

Boston

MA

Disclosures

AD declares that she has no competing interests.

Paul Tisi, MBBS, MS, FRCSEd

Medical Director/Consultant Vascular Surgeon

Bedford Hospital

Bedford

UK

Disclosures

PT declares that he has no competing interests.

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