Differentials

Common

Stroke

History

sudden numbness or weakness in the face, arm or leg, especially on one side of the body; confusion, difficulty talking or understanding speech (aphasia); unilateral or bilateral vision loss; difficulty walking, dizziness or loss of balance and coordination; loss of bodily functions

Exam

focal hemimotor or hemisensory deficit, somnolence, cranial nerve deficit(s)

1st investigation
  • CT head:

    decreased attenuation in regions of ischemia; increased attenuation in areas of hemorrhage

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Other investigations
  • MRI head:

    signal differentiation

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Transient ischemic attack

History

stroke symptoms lasting only a few minutes and usually <1 hour: sudden numbness or weakness in the face, arm or leg, especially on one side of the body; confusion, difficulty talking or understanding speech (aphasia); unilateral or bilateral vision loss; difficulty walking, dizziness, or loss of balance and coordination; loss of bodily functions

Exam

may be normal outside of attack; focal hemimotor or hemisensory deficit or cranial nerve deficits if acute

1st investigation
  • CT of brain:

    normal

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Other investigations
  • MRI/magnetic resonance angiography:

    may display stenosis in blood vessels to the brain

  • carotid ultrasound:

    may display significant stenosis of carotid arteries

  • echocardiogram:

    may display structural heart disease, thrombus, patent foramen ovale

  • ECG, holter monitor, loop recorder:

    may demonstrate atrial fibrillation

Joint buckling/instability/mechanical gait disorders

History

previous injury to joint, commonly from past athletic/physical activities

Exam

weakness in quadriceps muscles, hip flexors, knee flexors and extensors, dorsi and plantar flexion of the foot; pain in any joints of the lower extremities (including the feet) with movement; crepitus at involved joints; diminished range of motion or pain in range of motion (or excessive range of motion) due to prior injury

1st investigation
  • timed and untimed up-and-go test:

    signs of weakness when trying to stand

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Other investigations

    Deconditioning

    History

    lack of regular or adequate exercise; prolonged periods of immobility/sedentary behavior

    Exam

    impaired ability to rise from seated position; decreased flexibility; proximal muscle weakness (quadriceps); flexion contractures at knees (due to prolonged periods of immobility)

    1st investigation
    • timed and untimed up-and-go test:

      signs of weakness when trying to stand

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    Other investigations

      Osteosarcopenia

      History

      high number of falls per year, fracture history, reduced muscle strength

      Exam

      clinical features of osteoporosis (i.e., kyphosis, loss of height due to fractures), and of sarcopenia (i.e., muscle weakness, physical dysfunction, measured by either grip strength or chair stand test)

      1st investigation
      • dual energy x ray absorptiometry:

        reduced bone mineral density and bone quality; reduced muscle quantity or quality

      Other investigations
      • CT or MRI scan:

        reduced muscle quantity or quality

      • bio-electrical impedance analysis:

        reduced muscle quantity or quality

      Medication effects or polypharmacy

      History

      use of herbal medications/supplements and/or over-the-counter or prescription medications (use of 5 or more of any type of medication is particularly hazardous): benzodiazepines, antidepressants, anxiolytics, antipsychotics, opioids; sedatives and hypnotics (e.g., zolpidem), sildenafil, antihypertensives (specifically beta-blockers and peripheral vasodilators), digoxin, class Ia antiarrhythmics; nonsteroidal anti-inflammatory drugs; diabetes medications (e.g., insulin, thiazolidinediones) and associated hypoglycemia; highly anticholinergic drugs such as first-generation antihistamines (e.g., diphenhydramine), muscle relaxants, antimuscarinic drugs used for treatment of urinary incontinence, and vasodilators

      Exam

      no physical findings; chart review may show use of multiple or high-risk medications

      1st investigation
      • none:

        diagnosis is clinical

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      Other investigations

        Environmental or home hazards

        History

        loose rugs or carpets, wires, cords; clutter in home; poor lighting; slippery surfaces; absence of handrails; presence of garage/basement stairs, recent use of a cane or walker, living alone

        Exam

        full assessment beyond the scope of the usual clinic visit

        1st investigation
        • home visit:

          typically conducted by occupational therapist; may show correctable causes of falls

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        Other investigations

          Visual impairment

          History

          blurred vision, diplopia, complete or partial loss of vision

          Exam

          visual acuity may be impaired according to Snellen chart at 6 m or Rosenbaum card at 36 cm; fundoscopy may show macular degeneration; visual field exam/confrontation may show deficit in peripheral vision

          1st investigation
          • routine ophthalmology referral:

            screening for glaucoma and cataracts; dilated exam to confirm presence of macular degeneration or diabetic retinopathy; visual field exam to evaluate for peripheral vision deficits

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          Other investigations
          • emergency ophthalmology referral:

            for sudden loss of vision

          Peripheral sensory neuropathy

          History

          may report a feeling of unsteadiness when walking (especially on uneven surfaces, in poorly lit areas); loss of sensation in feet or hands; history may include diabetes or neurodegenerative disease (e.g., herniated disk); back or neck pain if disk disease present; medications taken may include risk of peripheral neuropathy (B6 supplement; amiodarone; chemotherapy)

          Exam

          Romberg sign; light touch, pinprick, proprioception, vibratory sense in lower extremities may show pattern of distribution of sensory impairment

          1st investigation
          • fasting blood glucose:

            elevated if diabetes is present

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          • serum electrolytes:

            may show abnormal sodium, potassium, or calcium

          • serum thyroid-stimulating hormone:

            high in primary hypothyroidism

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          • CBC:

            elevated MCV may suggest pernicious anemia

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          Other investigations
          • serum B12:

            low in pernicious anemia

          • CT of spine (neck or lumbar):

            possible disk disease

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          • MRI of spine (neck or lumbar):

            possible disk disease

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          • electromyogram of upper or lower extremities:

            indicates extent of sensory and motor defects

          Uncommon

          Vestibular dysfunction

          History

          dizziness, vertigo

          Exam

          nystagmus; signs of otitis media, including bulging tympanic membrane, Dix-Hallpike maneuver

          1st investigation
          • none:

            diagnosis is clinical and no specific tests are usually recommended; gait assessment may reveal underlying etiology

          Other investigations
          • MRI of internal auditory canal:

            may show acoustic neuroma

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          Gait disorders

          History

          history of disk disease, peripheral neuropathy (proprioceptive abnormality, e.g., secondary to diabetes), arthritis, previous hip or leg fracture, foot problems, joint infection, parkinsonism

          Exam

          type of gait may suggest an underlying disorder (e.g., shuffling gait in Parkinson disease or related disorder, wide-based gait in normal pressure hydrocephalus; steppage gait in foot drop); focused neurologic exam: positive Romberg evaluation may suggest presence of peripheral neuropathy

          1st investigation
          • none:

            diagnosis is clinical and no specific tests are usually required; gait assessment may reveal underlying etiology; referral to orthopedics or podiatry may be appropriate based on the symptoms and physical findings

          Other investigations
          • electromyogram of lower extremities:

            may provide information about motor and sensory abnormalities causing the gait or balance disturbance

          Dementia

          History

          change in mental status that is typically gradual and is associated with changes in functional status, such as activities of daily living (e.g., using the phone, doing household chores, cooking, shopping for groceries, managing medications or finances, arranging transportation); may have associated changes in mood (apathy, anxiety) or sensorium (visual hallucinations, delusions, paranoia), development of new or inappropriate behaviors, language difficulty; may be accompanied by motor symptoms (gait, balance problems, tremors)

          Exam

          difficulty explaining situations (e.g., daily activity, meal previous night); inability to perform common daily functions (e.g., button shirt, tie shoes, bathe, dress, toilet, personal hygiene, transfer and ambulate, feed self); confusion; inability to recall numbers; physical exam findings of gait and/or balance problems, tremors, bradykinesia, axial muscle rigidity, or focal neurologic abnormalities

          1st investigation
          • Folstein mini-mental state exam (MMSE):

            score ≤24 out of 30 indicates abnormality (score to be adjusted for age and level of education)

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          • Saint Louis University mental status exam:

            with high school education: 27-30 (normal), 21-26 (mild neurocognitive disorder), 1-20 (dementia); without high school education: 25-30 (normal), 20-24 (mild neurocognitive disorder), 1-19 (dementia) SLU: mental status exam Opens in new window

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          • Montreal Cognitive Assessment (MoCA):

            total possible score is 30 points; lower score indicates greater cognitive impairment

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          Other investigations
          • MRI head:

            increased white matter signal; focal areas of atrophy

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          • CT head:

            atrophy greater than normal for age

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          • routine laboratory tests (blood chemistry profile, CBC, thyroid-stimulating hormone, cobalamin, folate, erythrocyte sedimentation rate, C-reactive protein, urinalysis, urine microscopy and culture):

            to screen for partially reversible or reversible causes of dementia

          Delirium

          History

          acute or subacute time course; febrile illness; vomiting or diarrhea (causing electrolyte disturbance); drug use

          Exam

          fever, orthostasis, waxing/waning change in mental status and confusion

          1st investigation
          • serum electrolytes:

            abnormality of sodium, potassium or calcium and/or elevated BUN/creatinine

          • serum glucose:

            high or low

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          • CT head:

            normal

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          • CBC:

            elevated WBC or hematocrit

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          • urine analysis:

            positive for protein, nitrites, leukocytes, blood, glucose or ketones

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          • chest x-ray:

            consolidation

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          • ECG:

            arrhythmia or other evidence of electrolyte disturbance

          Other investigations
          • 4AT tool:

            consists of 4 items (alertness; AMT4 [Abbreviated Mental Test - 4]; attention; acute change); scored from 0 to 12, >4 indicates possible delirium, 1-3 indicates possible cognitive impairment 4AT Rapid Clinical Test for Delirium Opens in new window

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          • Confusion Assessment Method:

            diagnosis requires presence of features 1 and 2 and either 3 or 4: feature 1 assesses for an acute onset and fluctuating course; feature 2 assesses for inattention; feature 3 assesses for disorganized thinking; and feature 4 assesses for altered level of consciousness

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          Depression

          History

          feelings of sadness and/or worthlessness, thoughts of suicide, lack of energy, change in sleep habits (insomnia or excessive sleepiness), constipation, may express anger at family members or friends, change in appetite (weight loss or gain), difficulty with concentration, psychomotor slowing or irritability

          Exam

          subdued or depressive affect, listlessness, shuffling walk

          1st investigation
          Other investigations
          • Cornell Scale for Depression in Dementia:

            >10 suggests probable depression; >18 indicates definite depression

          Seizure

          History

          best history is a seizure witnessed by medical personnel

          Exam

          clinical suspicion needed for diagnosis of seizure; a postictal state may be observed if exam closely follows historical event of seizure

          1st investigation
          • electroencephalogram:

            may confirm focal area of abnormality to suggest a focus of seizure, persistent abnormality to support a diagnosis of epilepsy

          • CT head:

            usually normal or signs of focal ischemia

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          Other investigations
          • MRI head:

            may provide more specific clues to diagnosis compared with CT

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          Subdural hematoma

          History

          fall with associated head trauma with concurrent use of anticoagulation raises risk

          Exam

          sudden altered level of consciousness or mental status following fall or head trauma, with or without focal neurologic signs

          1st investigation
          • CT head:

            mass effect

            More
          Other investigations

            Syncope

            History

            loss of consciousness; potentially life-threatening accompanying symptoms include palpitations, chest pain, back pain, hematemesis and melena; history of precipitating factors, e.g., micturition, defecation, coughing, swallowing, hot environment, prolonged standing, severe pain and emotional distress; history of event occurring if wearing a tight collar or while shaving (especially older men; suggests carotid sinus syndrome); prodromal symptoms, e.g., nausea, sweating and lightheadedness; history of underlying heart disease

            Exam

            bradycardia, tachycardia, irregular pulse, cardiac murmur; sensory, motor, visual and speech deficits

            1st investigation
            • ECG:

              may show arrhythmia or heart block

              More
            • cardiac enzymes:

              elevated if underlying or resultant ischemia

            Other investigations
            • carotid sinus massage:

              positive result if reproduction of symptoms occurs; performed with care if suspicious of carotid sinus syndrome

            • Holter or event monitor:

              may further define arrhythmia suggested by ECG

            • exercise stress test:

              may indicate underlying ischemia

            Orthostatic hypotension

            History

            lightheadedness, dizziness, loss of consciousness or falls associated with a change in position from supine to seated or seated to standing; history of medications producing orthostatic hypotension (e.g., alpha blockers) or volume depletion (diuretics) may explain symptoms; however, some patients have no symptoms with changes in pulse or blood pressure from supine to standing

            Exam

            changes in blood pressure and pulse within 3 minutes associated with shifts in position from supine to seated or seated to standing; pulse and blood pressure can be checked immediately upon shift in position and within 1 to 3 minutes to identify changes; systolic blood pressure fall >20 mmHg from one position to another or diastolic blood pressure fall >10 mmHg from one position to another or pulse increase of 20 beats per minute with or without symptoms

            1st investigation
            • orthostatic challenge:

              blood pressure is measured lying and then standing; in the tilt table test, blood pressure and heart rate (by means of RR intervals on ECG) are measured continuously in the supine position and during passive head-up tilt (usually at 60°)

              More
            Other investigations
            • serum electrolytes:

              elevated BUN/creatinine may indicate volume depletion

            • ECG:

              may exclude arrhythmia or heart block

            • echocardiography:

              may reveal structural heart disease

            Substance misuse

            History

            excess intake of alcohol; use of analgesics (e.g., opioids) and/or recreational drugs; exposure to toxic agents (e.g., paint, paint thinners, wood varnishes), possibly occupation- or hobby-related

            Exam

            findings will depend on substance; nonspecific signs may include poor grooming, depression, malnutrition, bladder and bowel incontinence, recurring falls and head trauma

            1st investigation
            • urine toxicology screen:

              positive for detected illicit substance

            Other investigations

              Carotid sinus sensitivity

              History

              may be elicited by activities such as facial shaving, turning the head or wearing tight collars

              Exam

              carotid sinus massage produces asystole or reduced systolic blood pressure

              1st investigation
              • none:

                diagnosis is clinical

              Other investigations

                Postprandial hypotension

                History

                event based on history of observed fall coincident with meal times

                Exam

                no physical findings

                1st investigation
                • none:

                  diagnosis is clinical

                Other investigations

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