Differentials
Common
Stroke
History
sudden numbness or weakness in the face, arm or leg, especially on one side of the body; confusion, difficulty talking or understanding speech (aphasia); unilateral or bilateral vision loss; difficulty walking, dizziness or loss of balance and coordination; loss of bodily functions
Exam
focal hemimotor or hemisensory deficit, somnolence, cranial nerve deficit(s)
1st investigation
- CT head:
decreased attenuation in regions of ischemia; increased attenuation in areas of hemorrhage
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Other investigations
- MRI head:
signal differentiation
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Transient ischemic attack
History
stroke symptoms lasting only a few minutes and usually <1 hour: sudden numbness or weakness in the face, arm or leg, especially on one side of the body; confusion, difficulty talking or understanding speech (aphasia); unilateral or bilateral vision loss; difficulty walking, dizziness, or loss of balance and coordination; loss of bodily functions
Exam
may be normal outside of attack; focal hemimotor or hemisensory deficit or cranial nerve deficits if acute
1st investigation
- CT of brain:
normal
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Other investigations
- MRI/magnetic resonance angiography:
may display stenosis in blood vessels to the brain
- carotid ultrasound:
may display significant stenosis of carotid arteries
- echocardiogram:
may display structural heart disease, thrombus, patent foramen ovale
- ECG, holter monitor, loop recorder:
may demonstrate atrial fibrillation
Joint buckling/instability/mechanical gait disorders
History
previous injury to joint, commonly from past athletic/physical activities
Exam
weakness in quadriceps muscles, hip flexors, knee flexors and extensors, dorsi and plantar flexion of the foot; pain in any joints of the lower extremities (including the feet) with movement; crepitus at involved joints; diminished range of motion or pain in range of motion (or excessive range of motion) due to prior injury
1st investigation
- timed and untimed up-and-go test:
signs of weakness when trying to stand
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Other investigations
Deconditioning
History
lack of regular or adequate exercise; prolonged periods of immobility/sedentary behavior
Exam
impaired ability to rise from seated position; decreased flexibility; proximal muscle weakness (quadriceps); flexion contractures at knees (due to prolonged periods of immobility)
1st investigation
- timed and untimed up-and-go test:
signs of weakness when trying to stand
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Other investigations
Osteosarcopenia
History
high number of falls per year, fracture history, reduced muscle strength
Exam
clinical features of osteoporosis (i.e., kyphosis, loss of height due to fractures), and of sarcopenia (i.e., muscle weakness, physical dysfunction, measured by either grip strength or chair stand test)
1st investigation
- dual energy x ray absorptiometry:
reduced bone mineral density and bone quality; reduced muscle quantity or quality
Other investigations
- CT or MRI scan:
reduced muscle quantity or quality
- bio-electrical impedance analysis:
reduced muscle quantity or quality
Medication effects or polypharmacy
History
use of herbal medications/supplements and/or over-the-counter or prescription medications (use of 5 or more of any type of medication is particularly hazardous): benzodiazepines, antidepressants, anxiolytics, antipsychotics, opioids; sedatives and hypnotics (e.g., zolpidem), sildenafil, antihypertensives (specifically beta-blockers and peripheral vasodilators), digoxin, class Ia antiarrhythmics; nonsteroidal anti-inflammatory drugs; diabetes medications (e.g., insulin, thiazolidinediones) and associated hypoglycemia; highly anticholinergic drugs such as first-generation antihistamines (e.g., diphenhydramine), muscle relaxants, antimuscarinic drugs used for treatment of urinary incontinence, and vasodilators
Exam
no physical findings; chart review may show use of multiple or high-risk medications
1st investigation
- none:
diagnosis is clinical
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Other investigations
Environmental or home hazards
History
loose rugs or carpets, wires, cords; clutter in home; poor lighting; slippery surfaces; absence of handrails; presence of garage/basement stairs, recent use of a cane or walker, living alone
Exam
full assessment beyond the scope of the usual clinic visit
1st investigation
- home visit:
typically conducted by occupational therapist; may show correctable causes of falls
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Other investigations
Visual impairment
History
blurred vision, diplopia, complete or partial loss of vision
Exam
visual acuity may be impaired according to Snellen chart at 6 m or Rosenbaum card at 36 cm; fundoscopy may show macular degeneration; visual field exam/confrontation may show deficit in peripheral vision
1st investigation
- routine ophthalmology referral:
screening for glaucoma and cataracts; dilated exam to confirm presence of macular degeneration or diabetic retinopathy; visual field exam to evaluate for peripheral vision deficits
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Other investigations
- emergency ophthalmology referral:
for sudden loss of vision
Peripheral sensory neuropathy
History
may report a feeling of unsteadiness when walking (especially on uneven surfaces, in poorly lit areas); loss of sensation in feet or hands; history may include diabetes or neurodegenerative disease (e.g., herniated disk); back or neck pain if disk disease present; medications taken may include risk of peripheral neuropathy (B6 supplement; amiodarone; chemotherapy)
Exam
Romberg sign; light touch, pinprick, proprioception, vibratory sense in lower extremities may show pattern of distribution of sensory impairment
1st investigation
Uncommon
Vestibular dysfunction
History
dizziness, vertigo
Exam
nystagmus; signs of otitis media, including bulging tympanic membrane, Dix-Hallpike maneuver
1st investigation
- none:
diagnosis is clinical and no specific tests are usually recommended; gait assessment may reveal underlying etiology
Other investigations
- MRI of internal auditory canal:
may show acoustic neuroma
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Gait disorders
History
history of disk disease, peripheral neuropathy (proprioceptive abnormality, e.g., secondary to diabetes), arthritis, previous hip or leg fracture, foot problems, joint infection, parkinsonism
Exam
type of gait may suggest an underlying disorder (e.g., shuffling gait in Parkinson disease or related disorder, wide-based gait in normal pressure hydrocephalus; steppage gait in foot drop); focused neurologic exam: positive Romberg evaluation may suggest presence of peripheral neuropathy
1st investigation
- none:
diagnosis is clinical and no specific tests are usually required; gait assessment may reveal underlying etiology; referral to orthopedics or podiatry may be appropriate based on the symptoms and physical findings
Other investigations
- electromyogram of lower extremities:
may provide information about motor and sensory abnormalities causing the gait or balance disturbance
Dementia
History
change in mental status that is typically gradual and is associated with changes in functional status, such as activities of daily living (e.g., using the phone, doing household chores, cooking, shopping for groceries, managing medications or finances, arranging transportation); may have associated changes in mood (apathy, anxiety) or sensorium (visual hallucinations, delusions, paranoia), development of new or inappropriate behaviors, language difficulty; may be accompanied by motor symptoms (gait, balance problems, tremors)
Exam
difficulty explaining situations (e.g., daily activity, meal previous night); inability to perform common daily functions (e.g., button shirt, tie shoes, bathe, dress, toilet, personal hygiene, transfer and ambulate, feed self); confusion; inability to recall numbers; physical exam findings of gait and/or balance problems, tremors, bradykinesia, axial muscle rigidity, or focal neurologic abnormalities
1st investigation
- Folstein mini-mental state exam (MMSE):
score ≤24 out of 30 indicates abnormality (score to be adjusted for age and level of education)
More - Saint Louis University mental status exam:
with high school education: 27-30 (normal), 21-26 (mild neurocognitive disorder), 1-20 (dementia); without high school education: 25-30 (normal), 20-24 (mild neurocognitive disorder), 1-19 (dementia) SLU: mental status exam Opens in new window
More - Montreal Cognitive Assessment (MoCA):
total possible score is 30 points; lower score indicates greater cognitive impairment
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Other investigations
- MRI head:
increased white matter signal; focal areas of atrophy
More - CT head:
atrophy greater than normal for age
More - routine laboratory tests (blood chemistry profile, CBC, thyroid-stimulating hormone, cobalamin, folate, erythrocyte sedimentation rate, C-reactive protein, urinalysis, urine microscopy and culture):
to screen for partially reversible or reversible causes of dementia
Delirium
History
acute or subacute time course; febrile illness; vomiting or diarrhea (causing electrolyte disturbance); drug use
Exam
fever, orthostasis, waxing/waning change in mental status and confusion
1st investigation
- serum electrolytes:
abnormality of sodium, potassium or calcium and/or elevated BUN/creatinine
- serum glucose:
high or low
More - CT head:
normal
More - CBC:
elevated WBC or hematocrit
More - urine analysis:
positive for protein, nitrites, leukocytes, blood, glucose or ketones
More - chest x-ray:
consolidation
More - ECG:
arrhythmia or other evidence of electrolyte disturbance
Other investigations
- 4AT tool:
consists of 4 items (alertness; AMT4 [Abbreviated Mental Test - 4]; attention; acute change); scored from 0 to 12, >4 indicates possible delirium, 1-3 indicates possible cognitive impairment 4AT Rapid Clinical Test for Delirium Opens in new window
More - Confusion Assessment Method:
diagnosis requires presence of features 1 and 2 and either 3 or 4: feature 1 assesses for an acute onset and fluctuating course; feature 2 assesses for inattention; feature 3 assesses for disorganized thinking; and feature 4 assesses for altered level of consciousness
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Depression
History
feelings of sadness and/or worthlessness, thoughts of suicide, lack of energy, change in sleep habits (insomnia or excessive sleepiness), constipation, may express anger at family members or friends, change in appetite (weight loss or gain), difficulty with concentration, psychomotor slowing or irritability
Exam
subdued or depressive affect, listlessness, shuffling walk
1st investigation
- Geriatric Depression Scale:
>5 suggests depression; >10 strongly suggests depression
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Other investigations
- Cornell Scale for Depression in Dementia:
>10 suggests probable depression; >18 indicates definite depression
Seizure
History
best history is a seizure witnessed by medical personnel
Exam
clinical suspicion needed for diagnosis of seizure; a postictal state may be observed if exam closely follows historical event of seizure
1st investigation
- electroencephalogram:
may confirm focal area of abnormality to suggest a focus of seizure, persistent abnormality to support a diagnosis of epilepsy
- CT head:
usually normal or signs of focal ischemia
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Other investigations
- MRI head:
may provide more specific clues to diagnosis compared with CT
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Subdural hematoma
History
fall with associated head trauma with concurrent use of anticoagulation raises risk
Exam
sudden altered level of consciousness or mental status following fall or head trauma, with or without focal neurologic signs
1st investigation
- CT head:
mass effect
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Other investigations
Syncope
History
loss of consciousness; potentially life-threatening accompanying symptoms include palpitations, chest pain, back pain, hematemesis and melena; history of precipitating factors, e.g., micturition, defecation, coughing, swallowing, hot environment, prolonged standing, severe pain and emotional distress; history of event occurring if wearing a tight collar or while shaving (especially older men; suggests carotid sinus syndrome); prodromal symptoms, e.g., nausea, sweating and lightheadedness; history of underlying heart disease
Exam
bradycardia, tachycardia, irregular pulse, cardiac murmur; sensory, motor, visual and speech deficits
1st investigation
- ECG:
may show arrhythmia or heart block
More - cardiac enzymes:
elevated if underlying or resultant ischemia
Other investigations
- carotid sinus massage:
positive result if reproduction of symptoms occurs; performed with care if suspicious of carotid sinus syndrome
- Holter or event monitor:
may further define arrhythmia suggested by ECG
- exercise stress test:
may indicate underlying ischemia
Orthostatic hypotension
History
lightheadedness, dizziness, loss of consciousness or falls associated with a change in position from supine to seated or seated to standing; history of medications producing orthostatic hypotension (e.g., alpha blockers) or volume depletion (diuretics) may explain symptoms; however, some patients have no symptoms with changes in pulse or blood pressure from supine to standing
Exam
changes in blood pressure and pulse within 3 minutes associated with shifts in position from supine to seated or seated to standing; pulse and blood pressure can be checked immediately upon shift in position and within 1 to 3 minutes to identify changes; systolic blood pressure fall >20 mmHg from one position to another or diastolic blood pressure fall >10 mmHg from one position to another or pulse increase of 20 beats per minute with or without symptoms
1st investigation
- orthostatic challenge:
blood pressure is measured lying and then standing; in the tilt table test, blood pressure and heart rate (by means of RR intervals on ECG) are measured continuously in the supine position and during passive head-up tilt (usually at 60°)
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Other investigations
- serum electrolytes:
elevated BUN/creatinine may indicate volume depletion
- ECG:
may exclude arrhythmia or heart block
- echocardiography:
may reveal structural heart disease
Substance misuse
History
excess intake of alcohol; use of analgesics (e.g., opioids) and/or recreational drugs; exposure to toxic agents (e.g., paint, paint thinners, wood varnishes), possibly occupation- or hobby-related
Exam
findings will depend on substance; nonspecific signs may include poor grooming, depression, malnutrition, bladder and bowel incontinence, recurring falls and head trauma
1st investigation
- urine toxicology screen:
positive for detected illicit substance
Other investigations
Carotid sinus sensitivity
History
may be elicited by activities such as facial shaving, turning the head or wearing tight collars
Exam
carotid sinus massage produces asystole or reduced systolic blood pressure
1st investigation
- none:
diagnosis is clinical
Other investigations
Postprandial hypotension
History
event based on history of observed fall coincident with meal times
Exam
no physical findings
1st investigation
- none:
diagnosis is clinical
Other investigations
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